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Topical glycopyrrolate for patients with facial hyperhidrosis

Authors
 W.O. Kim  ;  H.K. Kil  ;  K.B. Yoon  ;  D.M. Yoon 
Citation
 BRITISH JOURNAL OF DERMATOLOGY, Vol.158(5) : 1094-1097, 2008 
Journal Title
 BRITISH JOURNAL OF DERMATOLOGY 
ISSN
 0007-0963 
Issue Date
2008
MeSH
Administration, Topical ; Adult ; Cholinergic Antagonists/therapeutic use* ; Facial Dermatoses/drug therapy* ; Female ; Glycopyrrolate/therapeutic use* ; Humans ; Hyperhidrosis/drug therapy* ; Male ; Sweating/drug effects
Keywords
craniofacial ; forehead hyperhidrosis ; gustatory ; topical glycopyrrolate
Abstract
BACKGROUND: Facial hyperhidrosis may negatively impact the quality of life. Although various conservative modalities have been suggested, the condition is not often treated successfully. OBJECTIVES: To examine whether topical glycopyrrolate could be an effective and safe treatment for facial hyperhidrosis. METHODS: Twenty-five patients with facial hyperhidrosis were enrolled and treated with 2% topical glycopyrrolate on one half of the forehead while the other half of the forehead was treated with a placebo. RESULTS: The sweat production rate of the half of the forehead treated with topical glycopyrrolate was significantly reduced to 37.6+/-2.8 mg min(-1) (mean+/-SEM) compared with 102.2+/-5.5 mg min(-1) at the placebo-treated half of the forehead (P<0.001). Patients evaluated their degree of anhidrosis as excellent in six (24%) patients, good in 16 (64%), fair in two (8%) and poor in one (4%). Twenty-four patients (96%) were partially or fully satisfied with their fair to excellent anhidrosis; only one patient (who developed a transient headache after treatment) was dissatisfied with its therapeutic effect. Only seven patients (28%) experienced recurrence within 1 day while 17 patients (68%) had recurrence within 2 days. One patient (4%) remained stable for up to 4 days. CONCLUSIONS: Topical glycopyrrolate application appears to be effective and safe for the treatment of excessive facial sweating in primary craniofacial and secondary gustatory hyperhidrosis following sympathectomy.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2008.08476.x/abstract
DOI
10.1111/j.1365-2133.2008.08476.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kil, Hae Keum(길혜금)
Kim, Won Oak(김원옥)
Yoon, Kyoung Bong(윤경봉) ORCID logo https://orcid.org/0000-0002-4167-1375
Yoon, Duck Mi(윤덕미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106288
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