Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer
Authors
Hye Jin Choi ; Nam-Kyu Kim ; Ki Chang Keum ; Seong Ha Cheon ; Sang Jun Shin ; Seung Hyuk Baik ; Jae Hee Choen ; Sun Young Rha ; Jae Kyung Roh ; Hei-Cheul Jeung ; Hyun Cheol Chung ; Joong Bae Ahn
Citation
RADIOTHERAPY AND ONCOLOGY, Vol.87(3) : 361-366, 2008
S-1 is a novel, oral fluoropyrimidine and a known radiosensitizer. We conducted a phase I trial to establish a schedule of S-1/irinotecan with standard pelvic radiotherapy as a preoperative treatment of locally advanced rectal cancer. Our findings suggest that this new combination is feasible and well tolerable