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Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer

Authors
 Hye Jin Choi  ;  Nam-Kyu Kim  ;  Ki Chang Keum  ;  Seong Ha Cheon  ;  Sang Jun Shin  ;  Seung Hyuk Baik  ;  Jae Hee Choen  ;  Sun Young Rha  ;  Jae Kyung Roh  ;  Hei-Cheul Jeung  ;  Hyun Cheol Chung  ;  Joong Bae Ahn 
Citation
 RADIOTHERAPY AND ONCOLOGY, Vol.87(3) : 361-366, 2008 
Journal Title
 RADIOTHERAPY AND ONCOLOGY 
ISSN
 0167-8140 
Issue Date
2008
MeSH
Adenocarcinoma/drug therapy* ; Adenocarcinoma/radiotherapy* ; Adenocarcinoma/surgery ; Adult ; Aged ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Combined Modality Therapy ; Drug Combinations ; Female ; Humans ; Male ; Maximum Tolerated Dose ; Middle Aged ; Neoadjuvant Therapy ; Oxonic Acid/administration & dosage* ; Oxonic Acid/adverse effects ; Radiation-Sensitizing Agents/adverse effects ; Radiation-Sensitizing Agents/therapeutic use* ; Radiotherapy Dosage ; Radiotherapy, High-Energy ; Rectal Neoplasms/drug therapy* ; Rectal Neoplasms/radiotherapy* ; Rectal Neoplasms/surgery ; Tegafur/administration & dosage* ; Tegafur/adverse effects
Keywords
S-1 ; Irinotecan ; Neoadjuvant ; Rectal cancer
Abstract
S-1 is a novel, oral fluoropyrimidine and a known radiosensitizer. We conducted a phase I trial to establish a schedule of S-1/irinotecan with standard pelvic radiotherapy as a preoperative treatment of locally advanced rectal cancer. Our findings suggest that this new combination is feasible and well tolerable
Full Text
http://www.sciencedirect.com/science/article/pii/S0167814008001953
DOI
10.1016/j.radonc.2008.04.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Cheon, Seong Ha(전성하)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Choi, Hye Jin(최혜진) ORCID logo https://orcid.org/0000-0001-5917-1400
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106265
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