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Significance of the injection timing of ephedrine to reduce the onset time of rocuronium

Authors
 D. W. Han  ;  D.-H. Chun  ;  T. D. Kweon  ;  Y.-S. Shin 
Citation
 Anaesthesia, Vol.63(8) : 856-860, 2008 
Journal Title
 Anaesthesia 
ISSN
 0003-2409 
Issue Date
2008
MeSH
Adult ; Androstanols/pharmacology* ; Anesthesia, General/methods ; Blood Pressure/drug effects ; Drug Administration Schedule ; Drug Synergism ; Ephedrine/administration & dosage* ; Ephedrine/pharmacology ; Heart Rate/drug effects ; Humans ; Injections, Intravenous ; Intubation, Intratracheal ; Male ; Middle Aged ; Neuromuscular Nondepolarizing Agents/pharmacology* ; Preanesthetic Medication/methods ; Vasoconstrictor Agents/administration & dosage* ; Vasoconstrictor Agents/pharmacology
Keywords
Adult ; Androstanols/pharmacology* ; Anesthesia, General/methods ; Blood Pressure/drug effects ; Drug Administration Schedule ; Drug Synergism ; Ephedrine/administration & dosage* ; Ephedrine/pharmacology ; Heart Rate/drug effects ; Humans ; Injections, Intravenous ; Intubation, Intratracheal ; Male ; Middle Aged ; Neuromuscular Nondepolarizing Agents/pharmacology* ; Preanesthetic Medication/methods ; Vasoconstrictor Agents/administration & dosage* ; Vasoconstrictor Agents/pharmacology
Abstract
We postulated that the onset time of rocuronium can be accelerated effectively if it is administered at the time when the effect of ephedrine on cardiac output has reached its maximum. Seventy-five male, anaesthetised, patients were randomly allocated to three groups. Ephedrine 70 microg.kg(-1) was administered at 4 min (Early) or 30 s (Late) before administering rocuronium. The control group received saline at 4 min and at 30 s before rocuronium. The onset time of rocuronium in the Early group was significantly shorter than in the Control group, but there was no difference in the onset time between the Late and Control groups. There were no significant differences in the intubating conditions of the three groups. Ephedrine 70 microg.kg(-1) can reduce the onset time of rocuronium effectively if rocuronium is administered at 4 min following the ephedrine injection, when the effect of ephedrine on cardiac output is expected to reach its maximum.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2008.05497.x/abstract
DOI
10.1111/j.1365-2044.2008.05497.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kweon, Tae Dong(권태동) ORCID logo https://orcid.org/0000-0002-5451-1856
Shin, Yang Sik(신양식)
Chun, Duk Hee(전덕희)
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106249
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