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The extract of Prunus persica flesh (PPFE) attenuates chemotherapy-induced hepatotoxicity in mice

Authors
 Chang Ki Lee  ;  Kwang Kyun Park  ;  Jae Kwan Hwang  ;  Sang Kook Lee  ;  Won Yoon Chung 
Citation
 PHYTOTHERAPY RESEARCH, Vol.22(2) : 223-227, 2008 
Journal Title
PHYTOTHERAPY RESEARCH
ISSN
 0951-418X 
Issue Date
2008
MeSH
Alanine Transaminase/metabolism ; Animals ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Aspartate Aminotransferases/metabolism ; Cell Line, Tumor ; Chemical and Drug Induced Liver Injury ; Cisplatin/adverse effects* ; Cisplatin/therapeutic use ; Glutathione/metabolism ; Lipid Peroxidation/drug effects ; Liver/drug effects* ; Liver/metabolism ; Liver/pathology ; Liver Diseases/pathology ; Liver Diseases/prevention & control* ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred ICR ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Organ Size/drug effects ; Phytotherapy ; Plant Extracts/pharmacology* ; Plant Extracts/therapeutic use ; Prunus/chemistry* ; Random Allocation
Keywords
Prunus persica flesh ; cisplatin ; hepatotoxicity
Abstract
Cisplatin (cis-diamminedichloroplatinum II) is one of the most effective chemotherapeutic agents used in the treatment of a variety of human solid tumors. However, its clinical use is limited due to severe toxicity. The pathogenesis of liver damage caused by cisplatin is generally considered to be oxidative damage. The aim of this study was to evaluate the protective effect of the ethanol extract of Prunus persica flesh (PPFE) against cisplatin-induced hepatotoxicity in animal models. In a xenograft model with the repeated administration of a low-dose cisplatin (5 mg/kg body weight) for 15 days, and in an acute toxicity model with a single administration of a high-dose cisplatin (45 mg/kg body weight) over a 16 h period, the consecutive administration of PPFE in combination with and prior to the cisplatin injection reversed the cisplatin-induced decrease in the liver weight as a percentage of total body weight, and the cisplatin-induced increases in the serum alanine aminotransferase and aspartate aminotransferase levels caused by liver damage. Moreover, the oral administration of PPFE significantly recovered the reduced glutathione level and inhibited lipid peroxidation in the cisplatin-treated mice. These results demonstrate that supplementation with PPFE might protect against cisplatin-induced toxicity in cancer patients.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ptr.2296/abstract
DOI
10.1002/ptr.2296
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
Lee, Chang Ki(이창기)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106191
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