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Cancer chemoprotective effects of Curcuma xanthorrhiza

 Jae Hee Park  ;  Kwang Kyun Park  ;  Mi Jeong Kim  ;  Jae Kwan Hwang  ;  Sun Kyu Park  ;  Won Yoon Chung 
 Phytotherapy Research, Vol.22(5) : 695-698, 2008 
Journal Title
 Phytotherapy Research 
Issue Date
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Anticarcinogenic Agents/chemistry ; Anticarcinogenic Agents/pharmacology* ; Anticarcinogenic Agents/therapeutic use ; Curcuma/chemistry* ; Dose-Response Relationship, Drug ; Ear/pathology ; Edema/chemically induced ; Edema/prevention & control ; Female ; Humans ; Methanol/chemistry ; Mice ; Mice, Inbred ICR ; Mutagenesis ; Phytotherapy ; Plant Extracts/chemistry ; Plant Extracts/pharmacology* ; Plant Extracts/therapeutic use ; Salmonella typhimurium/drug effects ; Salmonella typhimurium/genetics ; Skin Neoplasms/chemically induced ; Skin Neoplasms/prevention & control* ; Tetradecanoylphorbol Acetate
Curcuma xanthorrhiza ; antimutagenicity ; antiinflammatory activity ; multistage skin carcinogenesis ; chemoprevention
Curcuma xanthorrhiza Roxb. (Zingiberaceae) is a medicinal plant widely spread in South East Asia. In particular, it is commonly used not only for food and medicinal purposes in Indonesia, but also for the topical treatment of acne and skin inflammations as Thai traditional medicine. It was found that the methanol extract of C. xanthorrhiza inhibited significantly 7,12-dimethylbenz[a]anthracene (DMBA)-induced bacterial mutagenesis of Salmonella typhimurium TA98 and TA100 in the presence of S9, and the mutagenesis induced by H2O2 and tert-butylhydroperoxide in S. typhimurium TA102, respectively. In addition, 12-O-tetradecanolyphorbol-13-acetate(TPA)-induced mouse ear edema was markedly inhibited by pretreatment with C. xanthorrhiza extract. C. xanthorrhiza extract dose-dependently reduced ODC expression in mouse skin with TPA-induced acute inflammation. Furthermore, repeated treatment with 0.1% C. xanthorrhiza extract reduced the average number of tumors per mouse and the percentage of tumor-bearing mice in a multistage mouse skin carcinogenesis induced by DMBA and TPA. These results demonstrate that the methanol extract of C. xanthorrhiza possesses cancer chemopreventive potential.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Jeong(김미정)
Park, Kwang Kyun(박광균)
Park, Sun Kyu(박선규)
Park, Jae Hee(박재희)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
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