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Preceding orbital granulocytic sarcoma in an adult patient with acute myelogenous leukemia with t(8;21): a case study and review of the literature.

Authors
 Sang-Guk Lee  ;  Tae Sung Park  ;  June-Won Cheong  ;  Woo Ick Yang  ;  Jaewoo Song  ;  Kyung-A Lee  ;  Juwon Kim  ;  Yongjung Park  ;  Jong Rak Choi 
Citation
 CANCER GENETICS AND CYTOGENETICS , Vol.185(1) : 51-54, 2008 
Journal Title
 CANCER GENETICS AND CYTOGENETICS 
ISSN
 0165-4608 
Issue Date
2008
MeSH
Adult ; Chromosome Banding ; Chromosomes, Human, Pair 21* ; Chromosomes, Human, Pair 8* ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Karyotyping ; Leukemia, Myeloid, Acute/genetics* ; Leukemia, Myeloid, Acute/therapy ; Male ; Orbital Neoplasms/diagnosis ; Orbital Neoplasms/diagnostic imaging ; Orbital Neoplasms/pathology* ; Orbital Neoplasms/surgery ; Radiography ; Remission Induction ; Sarcoma, Myeloid/diagnosis ; Sarcoma, Myeloid/diagnostic imaging ; Sarcoma, Myeloid/pathology* ; Sarcoma, Myeloid/surgery ; Time Factors ; Translocation, Genetic*
Keywords
Adult ; Chromosome Banding ; Chromosomes, Human, Pair 21* ; Chromosomes, Human, Pair 8* ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Karyotyping ; Leukemia, Myeloid, Acute/genetics* ; Leukemia, Myeloid, Acute/therapy ; Male ; Orbital Neoplasms/diagnosis ; Orbital Neoplasms/diagnostic imaging ; Orbital Neoplasms/pathology* ; Orbital Neoplasms/surgery ; Radiography ; Remission Induction ; Sarcoma, Myeloid/diagnosis ; Sarcoma, Myeloid/diagnostic imaging ; Sarcoma, Myeloid/pathology* ; Sarcoma, Myeloid/surgery ; Time Factors ; Translocation, Genetic*
Abstract
A 25-year old man with a 30 month history of proptosis and pain of the right eye was referred to Severance Hospital of Yonsei University. Orbital computed tomography (CT) demonstrated a huge mass in the right retrobulbar orbit; an incisional biopsy and orbitotomy were performed for diagnosis and orbital soft tissue decompression. Subsequent histopathology disclosed sheets of mononuclear cells in the orbital mass, and immunohistochemical stains demonstrated positive results for myeloperoxidase and CD43, which supported the diagnosis of granulocytic sarcoma (GS). After his 1-year follow-up, the patient presented with pancytopenia, and an ensuing bone marrow aspiration revealed markedly hypercellular marrow replaced by many large abnormal myeloblasts. The patient was diagnosed with acute myelogenous leukemia with t(8;21) preceded by orbital GS. Orbital GS is primarily a disease of children, and extremely rare in adults. To the best of our knowledge, only four cases of this disease in adults have been reported in the literature. Our case is the first report of preceding orbital GS in an adult patient with a complex karyotype including t(8;21).
Full Text
http://www.sciencedirect.com/science/article/pii/S0165460808002720
DOI
10.1016/j.cancergencyto.2008.04.016
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Jung(박용정)
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Chung, Joo Won(정주원)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106177
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