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Diabetes mellitus does not affect jugular bulb oxygen saturation in patients undergoing off-pump coronary artery bypass graft surgery

 Young Jun Oh  ;  Ji Young Kim  ;  Jae Kwang Shim  ;  Kyung Jong Yoo  ;  Jong Wha Lee  ;  Young Lan Kwak 
 CIRCULATION JOURNAL, Vol.72(8) : 1259-1264, 2008 
Journal Title
Issue Date
Aged ; Cerebrovascular Circulation* ; Cognition Disorders/etiology ; Cognition Disorders/physiopathology ; Coronary Artery Bypass, Off-Pump*/adverse effects ; Coronary Artery Disease/complications ; Coronary Artery Disease/metabolism ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/surgery* ; Diabetes Mellitus, Type 2/complications* ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/surgery ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Jugular Veins/metabolism* ; Male ; Middle Aged ; Neuropsychological Tests ; Oximetry ; Oxygen/blood* ; Prospective Studies ; Time Factors ; Treatment Outcome
Coronary artery bypass surgery ; Diabetes mellitus ; Jugular bulb oxygen saturation ; Off-pump
BACKGROUND: Diabetes mellitus (DM) is associated with the impairment of cerebral oxygenation during cardiac surgery. The aim of the present study was to investigate the effects of DM on cerebral oxygenation assessed by jugular bulb oxygen saturation (SjvO2) in patients undergoing off-pump coronary artery bypass graft surgery (OPCAB) in a prospective controlled trial.

METHODS AND RESULTS: Twenty-three diabetic patients with glycosylated hemoglobin above 7.0% (DM group) and 23 non-diabetic patients (control group) undergoing OPCAB with no-touch aortic technique were included. A fiberoptic oximetry catheter was inserted into the jugular bulb. The lowest SjvO2 and the number of patients with cerebral desaturation, defined as SjvO2 less than 50% over 5 min, were recorded during coronary grafting. Three neurocognitive tests were done before surgery and at postoperative day 2 and 7. There were no differences in SjvO2 between the groups. Furthermore, the number of patients with cerebral desaturation and all neurocognitive test scores were similar between the 2 groups. None of the patients developed neurocognitive dysfunction.

CONCLUSIONS: Cerebral oxygenation in diabetic patients was similar to that of non-diabetic patients and well maintained above the critical level without resulting in clinically significant postoperative neurocognitive dysfunction during OPCAB with no-touch aortic technique.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Shim, Jae Kwang(심재광) ORCID logo https://orcid.org/0000-0001-9093-9692
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
Yoo, Kyung Jong(유경종) ORCID logo https://orcid.org/0000-0002-9858-140X
Lee, Jong Wha(이종화)
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