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The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae

Authors
 Jin-Yeon Park  ;  Heong-jwa Choi  ;  Miglena G.V. Prabagar  ;  Woo-Sung Choi  ;  Sun-Jong Kim  ;  Cheolho Cheong  ;  Chae Gyu Park  ;  Chan Young Chin  ;  Young-Sun Kang 
Citation
 NEUROSCIENCE LETTERS, Vol.450(3) : 246-251, 2009 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2009
MeSH
Animals ; Antigens, CD/metabolism* ; Bacterial Capsules/metabolism* ; Brain/metabolism* ; Brain/microbiology ; Brain/physiopathology ; Cell Adhesion Molecules/metabolism* ; Cells, Cultured ; Complement Activation/physiology ; Female ; Lectins, C-Type/metabolism* ; Meningitis, Pneumococcal/metabolism ; Meningitis, Pneumococcal/physiopathology ; Mice ; Mice, Inbred BALB C ; Microglia/metabolism* ; Microglia/microbiology ; Microglia/pathology ; Rats ; Rats, Sprague-Dawley ; Receptors, Cell Surface/metabolism* ; Streptococcus pneumoniae/metabolism*
Keywords
SIGN-R1 ; Rat CD209b ; Microglia ; Pattern-recognition receptors ; Capsular polysaccharides ; Pneumococcal meningitis
Abstract
Although Streptococcus pneumoniae is the major cause of meningitis, how it causes disease is poorly understood. The C-type lectin SIGN-R1 mediates the recently described SIGN-R1 complement activation pathway, which operates against capsular polysaccharides (CPSs) of S. pneumoniae in splenic marginal macrophages. Here, we demonstrate that SIGN-R1, as well as the rat SIGN-R1 homologue CD209b are expressed in most regions of mouse or rat brain, respectively. Moreover, both C-type lectins are obviously expressed on microglia, but not on neurons or astrocytes. We also found that rat CD209b mediates the uptake of dextran or CPS14 within the rat splenic marginal zone, similar to SIGN-R1. On microglia, rat CD209b also mediates the uptake of CPS14 of S. pneumoniae. Our findings strongly suggest that both rat CD209b and SIGN-R1 on microglia mediate the SIGN-R1 complement activation pathway against S. pneumoniae, and thereby plays an important role in the pathogenesis of pneumococcal meningitis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394008016431
DOI
10.1016/j.neulet.2008.11.070
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Park, Chae Gyu(박채규) ORCID logo https://orcid.org/0000-0003-1906-1308
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106076
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