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The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae

DC Field Value Language
dc.contributor.author박채규-
dc.date.accessioned2015-04-24T17:47:27Z-
dc.date.available2015-04-24T17:47:27Z-
dc.date.issued2009-
dc.identifier.issn0304-3940-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106076-
dc.description.abstractAlthough Streptococcus pneumoniae is the major cause of meningitis, how it causes disease is poorly understood. The C-type lectin SIGN-R1 mediates the recently described SIGN-R1 complement activation pathway, which operates against capsular polysaccharides (CPSs) of S. pneumoniae in splenic marginal macrophages. Here, we demonstrate that SIGN-R1, as well as the rat SIGN-R1 homologue CD209b are expressed in most regions of mouse or rat brain, respectively. Moreover, both C-type lectins are obviously expressed on microglia, but not on neurons or astrocytes. We also found that rat CD209b mediates the uptake of dextran or CPS14 within the rat splenic marginal zone, similar to SIGN-R1. On microglia, rat CD209b also mediates the uptake of CPS14 of S. pneumoniae. Our findings strongly suggest that both rat CD209b and SIGN-R1 on microglia mediate the SIGN-R1 complement activation pathway against S. pneumoniae, and thereby plays an important role in the pathogenesis of pneumococcal meningitis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent246~251-
dc.relation.isPartOfNEUROSCIENCE LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, CD/metabolism*-
dc.subject.MESHBacterial Capsules/metabolism*-
dc.subject.MESHBrain/metabolism*-
dc.subject.MESHBrain/microbiology-
dc.subject.MESHBrain/physiopathology-
dc.subject.MESHCell Adhesion Molecules/metabolism*-
dc.subject.MESHCells, Cultured-
dc.subject.MESHComplement Activation/physiology-
dc.subject.MESHFemale-
dc.subject.MESHLectins, C-Type/metabolism*-
dc.subject.MESHMeningitis, Pneumococcal/metabolism-
dc.subject.MESHMeningitis, Pneumococcal/physiopathology-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMicroglia/metabolism*-
dc.subject.MESHMicroglia/microbiology-
dc.subject.MESHMicroglia/pathology-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, Cell Surface/metabolism*-
dc.subject.MESHStreptococcus pneumoniae/metabolism*-
dc.titleThe C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorJin-Yeon Park-
dc.contributor.googleauthorHeong-jwa Choi-
dc.contributor.googleauthorMiglena G.V. Prabagar-
dc.contributor.googleauthorWoo-Sung Choi-
dc.contributor.googleauthorSun-Jong Kim-
dc.contributor.googleauthorCheolho Cheong-
dc.contributor.googleauthorChae Gyu Park-
dc.contributor.googleauthorChan Young Chin-
dc.contributor.googleauthorYoung-Sun Kang-
dc.identifier.doi10.1016/j.neulet.2008.11.070-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01718-
dc.relation.journalcodeJ02364-
dc.identifier.eissn1872-7972-
dc.identifier.pmid19095040-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304394008016431-
dc.subject.keywordSIGN-R1-
dc.subject.keywordRat CD209b-
dc.subject.keywordMicroglia-
dc.subject.keywordPattern-recognition receptors-
dc.subject.keywordCapsular polysaccharides-
dc.subject.keywordPneumococcal meningitis-
dc.contributor.alternativeNamePark, Chae Gyu-
dc.contributor.affiliatedAuthorPark, Chae Gyu-
dc.citation.volume450-
dc.citation.number3-
dc.citation.startPage246-
dc.citation.endPage251-
dc.identifier.bibliographicCitationNEUROSCIENCE LETTERS, Vol.450(3) : 246-251, 2009-
dc.identifier.rimsid57023-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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