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Liver stiffness measurement in combination with noninvasive markers for the improved diagnosis of B-viral liver cirrhosis.

Authors
 Seung Up Kim  ;  Sang Hoon Ahn  ;  Jun Yong Park  ;  Wonseok Kang  ;  Do Young Kim  ;  Young Nyun Park  ;  Chae Yoon Chon  ;  Kwang Hyub Han 
Citation
 JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.43(3) : 267-271, 2009 
Journal Title
JOURNAL OF CLINICAL GASTROENTEROLOGY
ISSN
 0192-0790 
Issue Date
2009
MeSH
Adult ; Alanine Transaminase/metabolism ; Aspartate Aminotransferases/metabolism ; Biomarkers/metabolism ; Biopsy ; Elasticity Imaging Techniques/methods* ; Female ; Hepatitis B, Chronic/diagnosis* ; Hepatitis B, Chronic/diagnostic imaging ; Hepatitis B, Chronic/metabolism ; Humans ; Liver/diagnostic imaging ; Liver/enzymology ; Liver/pathology* ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/metabolism ; Male ; Platelet Count ; Predictive Value of Tests ; Prospective Studies ; ROC Curve ; Sensitivity and Specificity ; Severity of Illness Index
Keywords
liver stiffness measurement ; chronic hepatitis B ; compensated liver cirrhosis ; chronic liver disease
Abstract
GOAL: To investigate the performance of liver stiffness measurement (LSM) in combination with available noninvasive markers in hepatitis B virus-related chronic liver disease.

BACKGROUND: Few noninvasive methods are available for predicting liver cirrhosis in chronic hepatitis B (CHB).

STUDY: Between January 2006 and June 2007, we studied 130 consecutive treatment-naive CHB patients who underwent liver biopsy (LB) and LSM. The aspartate to alanine aminotransferase ratio, age-platelet index (API), aspartate aminotransferase to platelet ratio index (APRI), LSM, and their combinations were compared with liver histology.

RESULTS: The API, APRI, and LSM, but not the aspartate to alanine aminotransferase ratio, correlated significantly with liver cirrhosis (all P<0.001). The diagnostic accuracy of LSM and API exceed that of the other diagnostic methods for predicting liver cirrhosis (area under the receiver operating characteristic curve=0.840 and 0.818). When LSM was combined with API and APRI, the diagnostic accuracy was improved markedly (area under the receiver operating characteristic curve =0.871, and 0.846). When both LSM and API results were in agreement, LB confirmed them in 89.1% (41/46) of cases for liver cirrhosis. LB could have been avoided in 41 (31.5%) of the 130 patients who were examined for the potential diagnosis of liver cirrhosis.

CONCLUSIONS: The combination of LSM and API can avoid unnecessary invasive LB procedures in CHB patients.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004836-200903000-00012&LSLINK=80&D=ovft
DOI
10.1097/MCG.0b013e31816f212e
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Suk(강원석)
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106014
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