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Liver stiffness measurement in combination with noninvasive markers for the improved diagnosis of B-viral liver cirrhosis.

DC Field Value Language
dc.contributor.author한광협-
dc.contributor.author강원석-
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author박영년-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author전재윤-
dc.date.accessioned2015-04-24T17:45:33Z-
dc.date.available2015-04-24T17:45:33Z-
dc.date.issued2009-
dc.identifier.issn0192-0790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106014-
dc.description.abstractGOAL: To investigate the performance of liver stiffness measurement (LSM) in combination with available noninvasive markers in hepatitis B virus-related chronic liver disease. BACKGROUND: Few noninvasive methods are available for predicting liver cirrhosis in chronic hepatitis B (CHB). STUDY: Between January 2006 and June 2007, we studied 130 consecutive treatment-naive CHB patients who underwent liver biopsy (LB) and LSM. The aspartate to alanine aminotransferase ratio, age-platelet index (API), aspartate aminotransferase to platelet ratio index (APRI), LSM, and their combinations were compared with liver histology. RESULTS: The API, APRI, and LSM, but not the aspartate to alanine aminotransferase ratio, correlated significantly with liver cirrhosis (all P<0.001). The diagnostic accuracy of LSM and API exceed that of the other diagnostic methods for predicting liver cirrhosis (area under the receiver operating characteristic curve=0.840 and 0.818). When LSM was combined with API and APRI, the diagnostic accuracy was improved markedly (area under the receiver operating characteristic curve =0.871, and 0.846). When both LSM and API results were in agreement, LB confirmed them in 89.1% (41/46) of cases for liver cirrhosis. LB could have been avoided in 41 (31.5%) of the 130 patients who were examined for the potential diagnosis of liver cirrhosis. CONCLUSIONS: The combination of LSM and API can avoid unnecessary invasive LB procedures in CHB patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent267~271-
dc.relation.isPartOfJOURNAL OF CLINICAL GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAlanine Transaminase/metabolism-
dc.subject.MESHAspartate Aminotransferases/metabolism-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHBiopsy-
dc.subject.MESHElasticity Imaging Techniques/methods*-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B, Chronic/diagnosis*-
dc.subject.MESHHepatitis B, Chronic/diagnostic imaging-
dc.subject.MESHHepatitis B, Chronic/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHLiver/diagnostic imaging-
dc.subject.MESHLiver/enzymology-
dc.subject.MESHLiver/pathology*-
dc.subject.MESHLiver Cirrhosis/diagnosis*-
dc.subject.MESHLiver Cirrhosis/diagnostic imaging-
dc.subject.MESHLiver Cirrhosis/metabolism-
dc.subject.MESHMale-
dc.subject.MESHPlatelet Count-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProspective Studies-
dc.subject.MESHROC Curve-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSeverity of Illness Index-
dc.titleLiver stiffness measurement in combination with noninvasive markers for the improved diagnosis of B-viral liver cirrhosis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorWonseok Kang-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorKwang Hyub Han-
dc.identifier.doi10.1097/MCG.0b013e31816f212e-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04268-
dc.contributor.localIdA00061-
dc.contributor.localIdA00654-
dc.contributor.localIdA01563-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ01319-
dc.identifier.eissn1539-2031-
dc.identifier.pmid18987556-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004836-200903000-00012&LSLINK=80&D=ovft-
dc.subject.keywordliver stiffness measurement-
dc.subject.keywordchronic hepatitis B-
dc.subject.keywordcompensated liver cirrhosis-
dc.subject.keywordchronic liver disease-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKang, Won Suk-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKang, Won Suk-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume43-
dc.citation.number3-
dc.citation.startPage267-
dc.citation.endPage271-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.43(3) : 267-271, 2009-
dc.identifier.rimsid56972-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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