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L1 cell adhesion molecule as a predictor for recurrence in pulmonary carcinoids and large-cell neuroendocrine tumors.

Authors
 HYO SONG KIM  ;  SEONG YOON YI  ;  HYUN JUNG JUN  ;  JIN SEOK AHN  ;  MYUNG-JU AHN  ;  JEEYUN LEE  ;  YOUNGWOOK KIM  ;  ZHENG YUN CUI  ;  HYO JEONG HONG  ;  JIN-MAN KIM  ;  SHENGJIN LI  ;  IN GYU HWANG  ;  KEUNCHIL PARK 
Citation
 APMIS, Vol.117(2) : 140-146, 2009 
Journal Title
 APMIS 
ISSN
 0903-4641 
Issue Date
2009
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoid Tumor/chemistry* ; Carcinoid Tumor/mortality ; Carcinoma, Large Cell/chemistry* ; Carcinoma, Large Cell/mortality ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms/chemistry* ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Neoplasm Recurrence, Local/chemistry* ; Neural Cell Adhesion Molecule L1/analysis* ; Neuroendocrine Tumors/chemistry* ; Neuroendocrine Tumors/mortality ; Survival Rate
Keywords
L1 ; cell adhesion molecules ; neuroendocrine tumors ; lung
Abstract
Pulmonary neuroendocrine tumors are a distinct subset of neoplasms with indolent to aggressive behavior. This study was conducted to evaluate the prognostic role of L1 cell adhesion molecule (L1CAM) in pulmonary neuroendocrine tumors. We retrospectively analyzed L1 expression in 55 cases of completely resected carcinoids and large-cell neuroendocrine carcinomas, by the immunohistochemistry with monoclonal antibody A10-A3 against human L1. L1 immunoreactivity was detected in 34 (61.8%) of 55 specimens. There was a significant correlation between L1 expression and the World Health Organization classification of this tumor (Spearman rank correlation, rho=0.60, p<0.001). With median follow-up of 52.0 months, the 5-year survival rate for patients with low expression of L1 (<20% of tumor cells stained) was significantly better compared with those with high expression of L1 (82.6% vs. 43.7%, p=0.005). L1 was also a significant independent predictor of disease-free survival, and patients with high L1 expression have a higher risk for recurrence compared with those with low L1 expression (hazard ratio, 3.0; 95% confidence interval, 1.2-8.3; p=0.034). L1 expression is significantly associated with aggressiveness and further studies with larger samples are needed to validate potential prognostic value for pulmonary neuroendocrine tumors.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0463.2009.02433.x/abstract
DOI
10.1111/j.1600-0463.2009.02433.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyo Song(김효송) ORCID logo https://orcid.org/0000-0002-0625-9828
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105982
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