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Smoking, diabetes and cardiovascular diseases in men in the Asia Pacific region.

Authors
 Andre Pascal KENGNE  ;  Koshi NAKAMURA  ;  Federica BARZI  ;  Tai Hing LAM  ;  Rachel HUXLEY  ;  Dongfeng GU  ;  Anushka PATEL  ;  Hyeon Chang KIM  ;  Mark WOODWARD 
Citation
 JOURNAL OF DIABETES, Vol.1(3) : 173-181, 2009 
Journal Title
 JOURNAL OF DIABETES 
ISSN
 1753-0393 
Issue Date
2009
MeSH
Adult ; Aged ; Asia, Southeastern ; Cardiovascular Diseases/epidemiology* ; Cohort Studies ; Confidence Intervals ; Coronary Disease/epidemiology ; Diabetes Mellitus/epidemiology* ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Male ; Middle Aged ; Pacific Islands ; Proportional Hazards Models ; Risk ; Risk Reduction Behavior ; Smoking/epidemiology* ; Smoking Cessation ; Stroke/epidemiology ; Young Adult
Keywords
cardiovascular diseases ; coronary disease ; diabetes mellitus ; smoking ; stroke
Abstract
BACKGROUND: To assess whether there is a statistical interaction between smoking and diabetes that is related to the risk of cardiovascular disease (CVD) in men in the Asia Pacific region. METHODS: An individual participant data meta-analysis was conducted on 34 cohort studies, involving 16 492 participants with diabetes (47.4% smokers) and 188 897 without (47.6% smokers). Hazard ratios (HR) and 95% confidence intervals (CI) were calculated for smoking (stratified by study and adjusted for age) for those with and without diabetes. RESULTS: In men with diabetes, the HR (95% CI) comparing current smokers with non-smokers was 1.42 (1.10-1.83) for coronary heart disease, 1.10 (0.88-1.37) for total stroke and 1.15 (0.98-1.35) for total CVD. The corresponding figures for men without diabetes were 1.47 (1.33-1.61), 1.27 (1.16-1.39) and 1.35 (1.27-1.44), respectively. There was no evidence of a statistical interaction between diabetes and current smoking, the number of cigarettes smoked per day or quitting smoking. Smoking cessation was associated with a 19% reduction in CVD risk, irrespective of diabetes status. CONCLUSIONS: The effects of cigarette smoking and smoking cessation are broadly similar in men with and without diabetes. In Asia, where there are high rates of smoking and a rapidly increasing prevalence of diabetes, strategies that encourage smokers to quit are likely to have huge benefits in terms of reducing the burden of CVD in men with diabetes.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1753-0407.2009.00028.x/abstract
DOI
10.1111/j.1753-0407.2009.00028.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105959
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