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Smoking, diabetes and cardiovascular diseases in men in the Asia Pacific region.

 Andre Pascal KENGNE  ;  Koshi NAKAMURA  ;  Federica BARZI  ;  Tai Hing LAM  ;  Rachel HUXLEY  ;  Dongfeng GU  ;  Anushka PATEL  ;  Hyeon Chang KIM  ;  Mark WOODWARD 
 JOURNAL OF DIABETES, Vol.1(3) : 173-181, 2009 
Journal Title
Issue Date
Adult ; Aged ; Asia, Southeastern ; Cardiovascular Diseases/epidemiology* ; Cohort Studies ; Confidence Intervals ; Coronary Disease/epidemiology ; Diabetes Mellitus/epidemiology* ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Male ; Middle Aged ; Pacific Islands ; Proportional Hazards Models ; Risk ; Risk Reduction Behavior ; Smoking/epidemiology* ; Smoking Cessation ; Stroke/epidemiology ; Young Adult
cardiovascular diseases ; coronary disease ; diabetes mellitus ; smoking ; stroke
BACKGROUND: To assess whether there is a statistical interaction between smoking and diabetes that is related to the risk of cardiovascular disease (CVD) in men in the Asia Pacific region. METHODS: An individual participant data meta-analysis was conducted on 34 cohort studies, involving 16 492 participants with diabetes (47.4% smokers) and 188 897 without (47.6% smokers). Hazard ratios (HR) and 95% confidence intervals (CI) were calculated for smoking (stratified by study and adjusted for age) for those with and without diabetes. RESULTS: In men with diabetes, the HR (95% CI) comparing current smokers with non-smokers was 1.42 (1.10-1.83) for coronary heart disease, 1.10 (0.88-1.37) for total stroke and 1.15 (0.98-1.35) for total CVD. The corresponding figures for men without diabetes were 1.47 (1.33-1.61), 1.27 (1.16-1.39) and 1.35 (1.27-1.44), respectively. There was no evidence of a statistical interaction between diabetes and current smoking, the number of cigarettes smoked per day or quitting smoking. Smoking cessation was associated with a 19% reduction in CVD risk, irrespective of diabetes status. CONCLUSIONS: The effects of cigarette smoking and smoking cessation are broadly similar in men with and without diabetes. In Asia, where there are high rates of smoking and a rapidly increasing prevalence of diabetes, strategies that encourage smokers to quit are likely to have huge benefits in terms of reducing the burden of CVD in men with diabetes.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
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