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Enhanced stem cell tracking via electrostatically assembled fluorescent SPION-peptide complexes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송호택 | - |
dc.date.accessioned | 2015-04-24T17:37:39Z | - |
dc.date.available | 2015-04-24T17:37:39Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0957-4484 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105760 | - |
dc.description.abstract | For cellular MRI there is a need to label cells with superparamagnetic iron oxide nanoparticles (SPION) that have multiple imaging moieties that are nontoxic and have increased NMR relaxation properties to improve the detection and tracking of therapeutic cells. Although increases in the relaxation properties of SPION have been accomplished, detection of tagged cells is limited by either poor cell labeling efficiency or low intracellular iron content. A strategy via a complex formation with transfection agents to overcome these obstacles has been reported. In this paper, we report a complex formation between negatively charged fluorescent monodisperse SPION and positively charged peptides and use the complex formation to improve the MR properties of labeled stem cells. As a result, labeled stem cells exhibited a strong fluorescent signal and enhanced T 2*-weighted MR imaging in vitro and in vivo in a flank tumor model | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | NANOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Chickens | - |
dc.subject.MESH | Ferric Compounds/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Iron/metabolism | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Magnetics* | - |
dc.subject.MESH | Mesenchymal Stromal Cells/cytology* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Microscopy, Fluorescence | - |
dc.subject.MESH | Peptides/metabolism* | - |
dc.subject.MESH | Phantoms, Imaging | - |
dc.subject.MESH | Staining and Labeling | - |
dc.subject.MESH | Static Electricity* | - |
dc.subject.MESH | Whole Body Imaging | - |
dc.title | Enhanced stem cell tracking via electrostatically assembled fluorescent SPION-peptide complexes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Jae-Ho Lee | - |
dc.contributor.googleauthor | Melissa A. Smith | - |
dc.contributor.googleauthor | Wei Liu | - |
dc.contributor.googleauthor | Eric M. Gold | - |
dc.contributor.googleauthor | Bobbi Lewis | - |
dc.contributor.googleauthor | Ho-Taek Song | - |
dc.contributor.googleauthor | Joseph A. Frank | - |
dc.identifier.doi | 10.1088/0957-4484/20/35/355102 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02080 | - |
dc.relation.journalcode | J02287 | - |
dc.identifier.eissn | 1361-6528 | - |
dc.identifier.pmid | 19671960 | - |
dc.subject.keyword | fluorescent SPION | - |
dc.subject.keyword | stem cell labeling | - |
dc.subject.keyword | multimodal imaging | - |
dc.subject.keyword | SPION-peptide complex | - |
dc.contributor.alternativeName | Song, Ho Taek | - |
dc.contributor.affiliatedAuthor | Song, Ho Taek | - |
dc.citation.volume | 20 | - |
dc.citation.number | 35 | - |
dc.citation.startPage | 355102 | - |
dc.identifier.bibliographicCitation | NANOTECHNOLOGY, Vol.20(35) : 355102, 2009 | - |
dc.identifier.rimsid | 43272 | - |
dc.type.rims | ART | - |
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