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소아 천식에서 유도 객담 내 CXCL13의 의의

Other Titles
 Clinical Implication of Sputum CXCLl3 in Children with Asthma 
Authors
 백지영  ;  최봉석  ;  이용주  ;  박여훈  ;  김경원  ;  손명현  ;  김규언 
Citation
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.19(4) : 420-428, 2009 
Journal Title
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지) 
ISSN
 1225-679X 
Issue Date
2009
Keywords
Asthma ; Chemokine ; CXCL13 ; Eosinophil ; ECP
Abstract
Purpose: CXCL13 is known to be a chemokine delivering B cell to the secondary lymphatic follicles, such as spleen, lymph nodes, and Peyer`s patches. Recently, there have been some reports that CXCL13 is important for T cell inflammation and expressed by Th17 cell which produces IL-17. This study attempted to examine the clinical implication of CXCL13 in children with asthma. Methods: This study included a total of 160 children aged 6 to 15 years who visited Severance Children`s Hospital. There were 80 children with asthma and 80 children without. the pulmonary function test and the methacholine challenge test were performed. Total eosinophi1 count, eosinophil cationic protein (ECP) and total IgE in serum and eosinophils, ECP and CXCL13 in sputum were measured. Results: the mean age of the subjects was 8.3±2.3 years for the asthma group and 9.3±2.5 years for the control group. the male to female ratio was 67.5% and 55.0% respectively. the sputum CXCL13 level for the asthma group was significantly higher than that level for the control group (P=0.003). This significance persisted even after adjustment for age and sex (P=0.010). the sputum CXCL13 level showed a positive correlation with that of sputum eosinophils (r=0.190, P=0.017) and ECP (r=0.285, P=0.002). Conclusion: Our results suggest that CXCL13 may play an important role in the pathophysiology of asthma related to eosinophilic inflammation. Further studies on sputum CXCL13 could help to reveal the role of chemokines in asthma
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Park, Yeo Hoon(박여훈)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Lee, Yong Ju(이용주) ORCID logo https://orcid.org/0000-0002-0796-2558
Choi, Bong Seok(최봉석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105693
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