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A comparative study of topical 5-aminolevulinic acid incubation times in photodynamic therapy with intense pulsed light for the treatment of inflammatory acne

Authors
 SANG HO OH  ;  DONG JIN RYU  ;  EUN CHUN HAN  ;  KWANG HOON LEE  ;  JU HEE LEE 
Citation
 DERMATOLOGIC SURGERY, Vol.35(12) : 1918-1926, 2009 
Journal Title
 DERMATOLOGIC SURGERY 
ISSN
 1076-0512 
Issue Date
2009
MeSH
Acne Vulgaris/drug therapy* ; Administration, Topical ; Adolescent ; Adult ; Aminolevulinic Acid/administration & dosage* ; Female ; Humans ; Male ; Photochemotherapy/methods* ; Photosensitizing Agents/administration & dosage* ; Time Factors ; Young Adult
Abstract
BACKGROUND: Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is used for effective treatment of facial acne vulgaris. OBJECTIVES: To determine which of two different incubation times (30 minutes and 3 hours) is more effective in PDT with intense pulsed light (IPL) for acne vulgaris. METHODS & MATERIALS: Twenty Korean subjects with moderate to severe acne were enrolled for a randomized, half-facial treatment study. Three sessions with short incubation with ALA plus IPL (30 minutes, n=9) or long incubation with ALA plus IPL (3 hours, n=11) on one side of the face and IPL alone on the other side were performed at 1-month intervals. RESULTS: All subjects showed improvement in inflammatory acne lesions after three sessions of ALA-PDT or IPL alone (p<.001 in all groups). the degree of improvement in inflammatory acne lesions was greater in the long incubation time group than the short incubation time group or the IPL-alone group, although the mean reduction of inflammatory acne lesions was statistically different only between the long incubation group and the IPL-only group (p=.01). There were no statistical differences between the short incubation group and IPL-alone group. All three groups had decreased sebum secretion after three sessions (p<.001 in all groups), but the differences between groups were not statistically significant. Only transient erythema and mild edema were reported for all treatment groups. CONCLUSION: PDT with a long ALA incubation time might be more adequate for a pronounced outcome with inflammatory acne.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1524-4725.2009.01315.x/abstract
DOI
10.1111/j.1524-4725.2009.01315.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Kwang Hoon(이광훈)
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105691
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