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A comparative study of topical 5-aminolevulinic acid incubation times in photodynamic therapy with intense pulsed light for the treatment of inflammatory acne
DC Field | Value | Language |
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dc.contributor.author | 이주희 | - |
dc.contributor.author | 오상호 | - |
dc.contributor.author | 이광훈 | - |
dc.date.accessioned | 2015-04-24T17:35:29Z | - |
dc.date.available | 2015-04-24T17:35:29Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1076-0512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105691 | - |
dc.description.abstract | BACKGROUND: Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is used for effective treatment of facial acne vulgaris. OBJECTIVES: To determine which of two different incubation times (30 minutes and 3 hours) is more effective in PDT with intense pulsed light (IPL) for acne vulgaris. METHODS & MATERIALS: Twenty Korean subjects with moderate to severe acne were enrolled for a randomized, half-facial treatment study. Three sessions with short incubation with ALA plus IPL (30 minutes, n=9) or long incubation with ALA plus IPL (3 hours, n=11) on one side of the face and IPL alone on the other side were performed at 1-month intervals. RESULTS: All subjects showed improvement in inflammatory acne lesions after three sessions of ALA-PDT or IPL alone (p<.001 in all groups). the degree of improvement in inflammatory acne lesions was greater in the long incubation time group than the short incubation time group or the IPL-alone group, although the mean reduction of inflammatory acne lesions was statistically different only between the long incubation group and the IPL-only group (p=.01). There were no statistical differences between the short incubation group and IPL-alone group. All three groups had decreased sebum secretion after three sessions (p<.001 in all groups), but the differences between groups were not statistically significant. Only transient erythema and mild edema were reported for all treatment groups. CONCLUSION: PDT with a long ALA incubation time might be more adequate for a pronounced outcome with inflammatory acne. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1918~1926 | - |
dc.relation.isPartOf | DERMATOLOGIC SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acne Vulgaris/drug therapy* | - |
dc.subject.MESH | Administration, Topical | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aminolevulinic Acid/administration & dosage* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Photochemotherapy/methods* | - |
dc.subject.MESH | Photosensitizing Agents/administration & dosage* | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Young Adult | - |
dc.title | A comparative study of topical 5-aminolevulinic acid incubation times in photodynamic therapy with intense pulsed light for the treatment of inflammatory acne | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | SANG HO OH | - |
dc.contributor.googleauthor | DONG JIN RYU | - |
dc.contributor.googleauthor | EUN CHUN HAN | - |
dc.contributor.googleauthor | KWANG HOON LEE | - |
dc.contributor.googleauthor | JU HEE LEE | - |
dc.identifier.doi | 10.1111/j.1524-4725.2009.01315.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02370 | - |
dc.contributor.localId | A03171 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J00707 | - |
dc.identifier.eissn | 1524-4725 | - |
dc.identifier.pmid | 19708873 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1524-4725.2009.01315.x/abstract | - |
dc.contributor.alternativeName | Lee, Ju Hee | - |
dc.contributor.alternativeName | Oh, Sang Ho | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.affiliatedAuthor | Oh, Sang Ho | - |
dc.contributor.affiliatedAuthor | Lee, Ju Hee | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.citation.volume | 35 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1918 | - |
dc.citation.endPage | 1926 | - |
dc.identifier.bibliographicCitation | DERMATOLOGIC SURGERY, Vol.35(12) : 1918-1926, 2009 | - |
dc.identifier.rimsid | 42670 | - |
dc.type.rims | ART | - |
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