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Serotypes of Aggregatibacter actinomycetemcomitans in patients with different ethnic backgrounds

Authors
 Ti-Sun Kim  ;  Patrick Frank  ;  Peter Eickholz  ;  Sigrun Eick  ;  Chong Kwan Kim 
Citation
 JOURNAL OF PERIODONTOLOGY, Vol.80(12) : 2020-2027, 2009 
Journal Title
 JOURNAL OF PERIODONTOLOGY 
ISSN
 0022-3492 
Issue Date
2009
MeSH
Actinobacillus Infections/ethnology ; Actinobacillus Infections/microbiology* ; Adult ; Aggregatibacter actinomycetemcomitans/classification* ; Aggressive Periodontitis/ethnology ; Aggressive Periodontitis/microbiology* ; Asian Continental Ancestry Group ; Bacterial Toxins/genetics ; Chronic Periodontitis/ethnology ; Chronic Periodontitis/microbiology* ; Dental Plaque/microbiology ; Dental Plaque Index ; Ethnic Groups* ; European Continental Ancestry Group ; Exotoxins/genetics ; Female ; Germany ; Gingival Hemorrhage/microbiology ; Humans ; Korea ; Male ; Middle Aged ; Operon/genetics ; Periodontal Attachment Loss/microbiology ; Periodontal Index ; Periodontal Pocket/microbiology ; Polymerase Chain Reaction ; Promoter Regions, Genetic/genetics ; Serotyping
Keywords
Actinobacillus actinomycetemcomitans ; aggressive periodontitis ; chronic periodontitis ; ethnic groups
Abstract
BACKGROUND: The identification of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) serotypes may add some important information to the understanding of the pathogenetic background of severe periodontal infections. This study compared serotypes of A. actinomycetemcomitans in two groups of periodontal patients with different ethnic backgrounds. METHODS: A total of 194 patients (96 Germans and 98 Koreans) with aggressive or severe chronic periodontitis participated in the study. Microbiologic analysis of pooled samples from subgingival plaque was performed by using a real-time polymerase chain reaction (PCR) test for A. actinomycetemcomitans. In patients who tested positive for A. actinomycetemcomitans, serotypes (a through f) were determined by nucleic acid-based methods. RESULTS: The prevalence of patients who tested positive for A. actinomycetemcomitans with the real-time PCR was comparable in both groups (Germans: 27.0%; Koreans: 22.2%). In German patients, the serotypes detected most frequently were b (33.3%), c (25.0%), and a (20.8%), whereas in Korean patients, the serotype distribution was different, with serotypes c (61.9%) and d (19.0%) accounting for >80% of the complete serotype spectrum. CONCLUSION: Even if the percentage of patients who tested positive for A. actinomycetemcomitans was identical in patients with generalized aggressive and severe chronic periodontitis and different ethnic backgrounds, the distribution of A. actinomycetemcomitans serotypes may exhibit marked differences.
Full Text
http://www.joponline.org/doi/abs/10.1902/jop.2009.090241
DOI
10.1902/jop.2009.090241
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105654
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