0 517

Cited 9 times in

Evaluative processing of ambivalent stimuli in patients with schizophrenia and depression: a [15O] H2O PET study

Authors
 JAE-JIN KIM  ;  HAE-JEONG PARK  ;  YOUNG-CHUL JUNG  ;  JI WON CHUN  ;  HYE SUN KIM  ;  JEONG HO SEOK  ;  NAM WOOK KIM  ;  IL HO PARK  ;  MAENG-GUN OH  ;  JONG DOO LEE 
Citation
 JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, Vol.15(6) : 990-1001, 2009 
Journal Title
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
ISSN
 1355-6177 
Issue Date
2009
MeSH
Adult ; Brain/diagnostic imaging ; Brain/pathology ; Brain Mapping ; Choice Behavior/physiology ; Comprehension/physiology ; Decision Making/physiology* ; Depression/diagnostic imaging* ; Depression/physiopathology* ; Female ; Functional Laterality/physiology ; Humans ; Male ; Neuropsychological Tests ; Oxygen Isotopes ; Positron-Emission Tomography/methods ; Schizophrenia/diagnostic imaging* ; Schizophrenia/physiopathology ; Schizophrenic Psychology* ; Statistics as Topic ; Water ; Young Adult
Keywords
Confl ict resolution ; bivalence ; Schizophrenia ; Depression:PET ; Prefrontal cortex ; Cerebellum
Abstract
Decision making in an emotionally conflicting situation is important in social life. We aimed to address the similarity and disparity of neural correlates involved in processing ambivalent stimuli in patients with schizophrenia and patients with depression. Behavioral task-related hemodynamic responses were measured using [15O]H2O positron emission tomography (PET) in 12 patients with schizophrenia and 12 patients with depression. The task was a modified word-stem completion task, which was designed to evoke ambivalence in forced and non-forced choice conditions. The prefrontal cortex and the cerebellum were found to show increased activity in the healthy control group. In the schizophrenia group, activity in these two regions was negligible. In the depression group, the pattern of activity was altered and a functional compensatory recruitment of the inferior parietal regions was suggested. The prefrontal cortex seems to be associated with the cognitive control to resolve the conflict toward the ambivalent stimuli, whereas the cerebellum reflects the sustained working memory to search for compromise alternatives. The deficit of cerebellar activation in the schizophrenia group might underlie the inability to search and consider compromising responses for conflict resolution
Full Text
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=6542576
DOI
10.1017/S1355617709990403
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Lee, Jong Doo(이종두)
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105483
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links