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Muscle weakness after repeated injection of botulinum toxin type A evaluated according to bite force measurement of human masseter muscle

Authors
 KI SEO KIM  ;  YOUNG SUB BYUN  ;  YONG JEONG KIM  ;  SEONG TAEK KIM 
Citation
 DERMATOLOGIC SURGERY, Vol.35(12) : 1902-1907, 2009 
Journal Title
 DERMATOLOGIC SURGERY 
ISSN
 1076-0512 
Issue Date
2009
MeSH
Adult ; Bite Force* ; Botulinum Toxins, Type A/administration & dosage ; Botulinum Toxins, Type A/pharmacology* ; Female ; Humans ; Hypertrophy/drug therapy ; Injections, Intramuscular ; Male ; Masseter Muscle/drug effects* ; Masseter Muscle/pathology ; Muscle Weakness/chemically induced* ; Neuromuscular Agents/administration & dosage ; Neuromuscular Agents/pharmacology*
Abstract
BACKGROUND: Botulinum toxin type A (BTX-A) has been applied successfully to treat masseteric hypertrophy, but it can cause muscle weakness. OBJECTIVE: To measure the change in maximum bite force (MBF) after BTX-A injection into the human masseter muscle and to evaluate the influence of a booster (repeated) injection. METHODS: Thirty volunteers completed 18-week follow-up, and MBF was measured. At 18 weeks after the first injection, a booster injection was given to 14 patients, and they were followed up until 18 weeks from the booster injection. RESULTS: Mean MBF was approximately 20% lower at 2 weeks than before the injection, and it recovered gradually after 4 weeks to return to the preinjection level at 12 weeks. MBF differed significantly between before the injection and at 2, 4, and 8 weeks after the injection (p<.05). In the booster injection group (n=14), MBF was markedly lower at 6 weeks (p<.05), and it recovered gradually in 12 weeks. CONCLUSION: MBF was significantly lower after booster injection of BTX-A into the human masseter muscle, but it gradually recovered in a predictable pattern, and the degree of discomfort experienced by the subjects had little effect on normal mastication
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1524-4725.2009.01319.x/abstract
DOI
10.1111/j.1524-4725.2009.01319.x
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Seo(김기서)
Kim, Seong Taek(김성택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105461
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