Cited 113 times in
Association of BRAFV600E mutation with poor clinical prognostic factors and US features in Korean patients with papillary thyroid microcarcinoma.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽진영 | - |
dc.contributor.author | 김민정 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 문희정 | - |
dc.contributor.author | 정웅윤 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-04-24T17:28:01Z | - |
dc.date.available | 2015-04-24T17:28:01Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105452 | - |
dc.description.abstract | PURPOSE: To evaluate the association of known prognostic factors with the BRAF(V600E) mutation and its association with ultrasonographic (US) features in Korean patients with papillary thyroid microcarcinoma (PTMC). MATERIALS AND METHODS: This retrospective study was institutional review board approved; informed consent was not required from patients. From July 2008 to November 2008, 339 consecutive patients underwent surgery for PTMC. US-guided fine-needle aspiration biopsy was performed to evaluate BRAF status in thyroid nodules before surgery. Logistic regression analysis was performed to assess the association between BRAF status, determined by using clinicopathologic factors, and several US features. RESULTS: Univariate analysis revealed an association between the BRAF(V600E) mutation and both tumor size and extracapsular invasion. Tumor size, extracapsular invasion, and high TNM stage (III and IV) were significantly associated with BRAF(V600E) in multivariate analysis. BRAF(V600E) was not significantly associated with any US features. CONCLUSION: The BRAF(V600E) mutation can be used as a potential prognostic factor in PTMC patients in a BRAF(V600E)-prevalent area. Future studies will be needed to determine how this information can be used to alter patient care. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 854~860 | - |
dc.relation.isPartOf | RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biopsy, Fine-Needle | - |
dc.subject.MESH | Carcinoma, Papillary/diagnostic imaging* | - |
dc.subject.MESH | Carcinoma, Papillary/epidemiology | - |
dc.subject.MESH | Carcinoma, Papillary/genetics* | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Interpretation, Computer-Assisted | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proto-Oncogene Proteins B-raf/genetics* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Thyroid Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Thyroid Neoplasms/epidemiology | - |
dc.subject.MESH | Thyroid Neoplasms/genetics* | - |
dc.subject.MESH | Ultrasonography | - |
dc.title | Association of BRAFV600E mutation with poor clinical prognostic factors and US features in Korean patients with papillary thyroid microcarcinoma. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Jin Young Kwak | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.contributor.googleauthor | Woong Youn Chung | - |
dc.contributor.googleauthor | Hee Jung Moon | - |
dc.contributor.googleauthor | Min Jung Kim | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.identifier.doi | 10.1148/radiol.2533090471 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00182 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A03674 | - |
dc.contributor.localId | A04182 | - |
dc.contributor.localId | A00473 | - |
dc.relation.journalcode | J02596 | - |
dc.identifier.eissn | 1527-1315 | - |
dc.identifier.pmid | 19710001 | - |
dc.identifier.url | http://pubs.rsna.org/doi/full/10.1148/radiol.2533090471?pubCode=cgi | - |
dc.contributor.alternativeName | Kwak, Jin Young | - |
dc.contributor.alternativeName | Kim, Min Jung | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Moon, Heui Jeong | - |
dc.contributor.alternativeName | Chung, Woung Youn | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Kwak, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Heui Jeong | - |
dc.contributor.affiliatedAuthor | Chung, Woung Youn | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Kim, Min Jung | - |
dc.citation.volume | 253 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 854 | - |
dc.citation.endPage | 860 | - |
dc.identifier.bibliographicCitation | RADIOLOGY, Vol.253(3) : 854-860, 2009 | - |
dc.identifier.rimsid | 44273 | - |
dc.type.rims | ART | - |
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