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Effects of methylphenidate on cerebral glucose metabolism in patients with impaired consciousness after acquired brain injury

Authors
 Yong Wook Kim  ;  Ji-Cheol Shin  ;  Young-sil An 
Citation
 CLINICAL NEUROPHARMACOLOGY, Vol.32(6) : 335-339, 2009 
Journal Title
 CLINICAL NEUROPHARMACOLOGY 
ISSN
 0362-5664 
Issue Date
2009
MeSH
Adult ; Brain Chemistry ; Brain Injuries/complications ; Brain Injuries/drug therapy* ; Brain Injuries/metabolism ; Brain Mapping/methods ; Central Nervous System Stimulants/therapeutic use* ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/drug effects* ; Cerebral Cortex/metabolism ; Consciousness Disorders/drug therapy* ; Consciousness Disorders/etiology ; Consciousness Disorders/metabolism ; Female ; Fluorodeoxyglucose F18/pharmacokinetics ; Glucose/metabolism* ; Humans ; Male ; Methylphenidate/therapeutic use* ; Positron-Emission Tomography ; Prospective Studies ; Radiopharmaceuticals/pharmacokinetics ; Severity of Illness Index
Keywords
methylphenidate ; cerebral glucose metabolism ; consciousness ; acquired brain injury
Abstract
OBJECTIVES: To evaluate the effects of methylphenidate on cerebral glucose metabolism in patients with impaired consciousness after acquired brain injury. METHODS: Fourteen patients with impaired consciousness after acquired brain injury were enrolled in our study. We evaluated the level of consciousness with the Glasgow Coma Scale upon initial evaluation and at the 6-week follow-up after methylphenidate medication (0.3 mg/kg per day, which was administered twice daily). Positron emission tomography was performed before and after 6 weeks of medication, and the effects of methylphenidate on cerebral glucose metabolism were analyzed using statistical parametric mapping. RESULTS: The statistical parametric mapping analysis indicated that significant increases of the cerebral glucose metabolism after methylphenidate therapy, compared with the initial positron emission tomographic image, were most evident in the left precuneus, the right posterior cingulated and the right retrosplenial cortices, and the right inferior parietal cortex (P < 0.001). In addition, cerebral glucose metabolism was significantly increased in the right precuneus, the right superior and middle temporal gyri, and bilateral middle occipital gyri (P < 0.005). In the correlation analysis, improvement of the Glasgow Coma Scale scores after methylphenidate medication was significantly associated with increased cerebral glucose metabolism in the bilateral precuneus, the bilateral middle occipital gyri, and right middle frontal gyrus. CONCLUSIONS: Our findings suggest that the posteromedial parietal cortex, which is part of the neural network for consciousness, may be the relevant structure for the pharmacological response to methylphenidate treatment in patients with impaired consciousness after acquired brain injury
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00002826-200911000-00006&LSLINK=80&D=ovft
DOI
10.1097/WNF.0b013e3181b40678
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Shin, Ji Cheol(신지철) ORCID logo https://orcid.org/0000-0002-1133-1361
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105448
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