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Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma

Authors
 Eun Soo Kim  ;  Seung-Hyun Kim  ;  Kyung Won Kim  ;  Hae-Sim Park  ;  Eun Soon Shin  ;  Jong Eun Lee  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
Citation
 EUROPEAN JOURNAL OF PEDIATRICS, Vol.168(12) : 1483-1490, 2009 
Journal Title
 EUROPEAN JOURNAL OF PEDIATRICS 
ISSN
 0340-6199 
Issue Date
2009
MeSH
Adolescent ; Asian Continental Ancestry Group/genetics ; Asthma/genetics* ; Child ; Female ; Genetic Predisposition to Disease/genetics* ; Genotype ; Haplotypes ; Humans ; Male ; Polymorphism, Single Nucleotide ; Receptors, IgE/genetics*
Keywords
Atopy ; Bronchial asthma ; FcɛR1β polymorphism
Abstract
INTRODUCTION: IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (Fc(epsilon)R1) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic disease including bronchial asthma. MATERIALS AND METHODS: We genotyped 650 children for allelic determinants at two polymorphic sites, -109T/C and E237G, in the Fc(epsilon)R1beta gene by SNP-IT assays using the SNP stream 25K system. RESULTS: Distributions of the genotype and allele frequencies of Fc(epsilon)R1beta -109T/C and E237G polymorphisms were significantly associated with atopy (P < 0.05) and elevated serum IgE levels. However, differences in the E237G polymorphism did not reach statistical significance after adjustment for multiple comparisons. The genotypes TC or CC at -109T/C were associated with decreased forced expiratory flow(25-75%) in children with asthma (P < 0.05), but this did not reach statistical significance after correction for multiple comparisons. In addition, haplotype 1 (T-A) was associated with atopy susceptibility (P = 0.0069). Analysis of genotype distributions of haplotypes demonstrated a significantly lower PC(20) for homozygous -/- diploids compared with homozygous Ht1/Ht1 (P = 0.0261). CONCLUSION: Polymorphisms in the Fc(epsilon)R1beta gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways of asthmatic patients.
Full Text
http://link.springer.com/article/10.1007%2Fs00431-009-0960-x
DOI
10.1007/s00431-009-0960-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Kim, Eun Soo(김은수)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105432
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