Cited 9 times in
Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma
DC Field | Value | Language |
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dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 김은수 | - |
dc.contributor.author | 손명현 | - |
dc.date.accessioned | 2015-04-24T17:27:22Z | - |
dc.date.available | 2015-04-24T17:27:22Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0340-6199 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105432 | - |
dc.description.abstract | INTRODUCTION: IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (Fc(epsilon)R1) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic disease including bronchial asthma. MATERIALS AND METHODS: We genotyped 650 children for allelic determinants at two polymorphic sites, -109T/C and E237G, in the Fc(epsilon)R1beta gene by SNP-IT assays using the SNP stream 25K system. RESULTS: Distributions of the genotype and allele frequencies of Fc(epsilon)R1beta -109T/C and E237G polymorphisms were significantly associated with atopy (P < 0.05) and elevated serum IgE levels. However, differences in the E237G polymorphism did not reach statistical significance after adjustment for multiple comparisons. The genotypes TC or CC at -109T/C were associated with decreased forced expiratory flow(25-75%) in children with asthma (P < 0.05), but this did not reach statistical significance after correction for multiple comparisons. In addition, haplotype 1 (T-A) was associated with atopy susceptibility (P = 0.0069). Analysis of genotype distributions of haplotypes demonstrated a significantly lower PC(20) for homozygous -/- diploids compared with homozygous Ht1/Ht1 (P = 0.0261). CONCLUSION: Polymorphisms in the Fc(epsilon)R1beta gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways of asthmatic patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1483~1490 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PEDIATRICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics | - |
dc.subject.MESH | Asthma/genetics* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease/genetics* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Haplotypes | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Receptors, IgE/genetics* | - |
dc.title | Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Eun Soo Kim | - |
dc.contributor.googleauthor | Seung-Hyun Kim | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Hae-Sim Park | - |
dc.contributor.googleauthor | Eun Soon Shin | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Kyu-Earn Kim | - |
dc.identifier.doi | 10.1007/s00431-009-0960-x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00805 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01967 | - |
dc.relation.journalcode | J00839 | - |
dc.identifier.eissn | 1432-1076 | - |
dc.identifier.pmid | 19288130 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00431-009-0960-x | - |
dc.subject.keyword | Atopy | - |
dc.subject.keyword | Bronchial asthma | - |
dc.subject.keyword | FcɛR1β polymorphism | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Kim, Eun Soo | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Eun Soo | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.citation.volume | 168 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1483 | - |
dc.citation.endPage | 1490 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PEDIATRICS, Vol.168(12) : 1483-1490, 2009 | - |
dc.identifier.rimsid | 51686 | - |
dc.type.rims | ART | - |
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