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Corticotropin-releasing factor decreases IL-18 in the monocyte-derived dendritic cell.

 Hee Jung Lee  ;  Yeon Sook Kwon  ;  Chang Ook Park  ;  Sang Ho Oh  ;  Ju Hee Lee  ;  Wen Hao Wu  ;  Nam Soo Chang  ;  Min-Geol Lee  ;  Kwang Hoon Lee 
 EXPERIMENTAL DERMATOLOGY, Vol.18(3) : 199-204, 2009 
Journal Title
Issue Date
Case-Control Studies ; Cells, Cultured ; Chemokine CCL17/metabolism ; Chemokine CCL22/metabolism ; Chemokines, CC/metabolism ; Corticotropin-Releasing Hormone/physiology* ; Dendritic Cells/metabolism* ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Humans ; Interleukin-18/metabolism* ; Interleukin-6/metabolism ; Monocytes/metabolism* ; Protein Isoforms/metabolism ; RNA, Messenger/metabolism ; Receptors, Corticotropin-Releasing Hormone/metabolism
atopic dermatitis ; corticotropin‐releasing factor ; dendritic cell ; IL‐18
Recent evidence suggests that crosstalk between mast cells, nerves and keratinocytes might be involved in the exacerbation of inflammatory conditions by stress, but the mechanism by which this occurs remains unclear. Corticotropin-releasing factor (CRF), which activates the hypothalamo-pituitary-adrenal (HPA) axis under stress, also has pro-inflammatory peripheral effects. However, there have been no reports about CRF receptor expression and the functional role of CRF in the dendritic cell (DC), which is considered to be the link between allergen uptake and the clinical manifestations of allergic diseases, such as atopic dermatitis. The purpose of this study was to investigate the expression of CRF receptors and the functional role of CRF in the monocyte-derived DC (MoDC) of atopic dermatitis patients and non-atopic healthy controls. In this study, mRNAs for CRF-R1alpha and 1beta, as well as the CRF-R1 protein, were detected in MoDCs. CRF-R2alpha (but not R2beta or R2gamma) mRNA and the CRF-R2 protein were present in MoDCs. Exposure of DCs to CRF resulted in a decrease of IL-18 in both atopic dermatitis patients and non-atopic healthy controls. However, CRF did not alter the expression of IL-6, CCL17, CCL18, and CCL22. Therefore, our results demonstrate that CRF could modulate immune responses by acting directly upon DCs.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Kwang Hoon(이광훈)
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
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