Cited 18 times in
Corticotropin-releasing factor decreases IL-18 in the monocyte-derived dendritic cell.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이주희 | - |
dc.contributor.author | 오상호 | - |
dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이민걸 | - |
dc.date.accessioned | 2015-04-24T17:27:14Z | - |
dc.date.available | 2015-04-24T17:27:14Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105428 | - |
dc.description.abstract | Recent evidence suggests that crosstalk between mast cells, nerves and keratinocytes might be involved in the exacerbation of inflammatory conditions by stress, but the mechanism by which this occurs remains unclear. Corticotropin-releasing factor (CRF), which activates the hypothalamo-pituitary-adrenal (HPA) axis under stress, also has pro-inflammatory peripheral effects. However, there have been no reports about CRF receptor expression and the functional role of CRF in the dendritic cell (DC), which is considered to be the link between allergen uptake and the clinical manifestations of allergic diseases, such as atopic dermatitis. The purpose of this study was to investigate the expression of CRF receptors and the functional role of CRF in the monocyte-derived DC (MoDC) of atopic dermatitis patients and non-atopic healthy controls. In this study, mRNAs for CRF-R1alpha and 1beta, as well as the CRF-R1 protein, were detected in MoDCs. CRF-R2alpha (but not R2beta or R2gamma) mRNA and the CRF-R2 protein were present in MoDCs. Exposure of DCs to CRF resulted in a decrease of IL-18 in both atopic dermatitis patients and non-atopic healthy controls. However, CRF did not alter the expression of IL-6, CCL17, CCL18, and CCL22. Therefore, our results demonstrate that CRF could modulate immune responses by acting directly upon DCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 199~204 | - |
dc.relation.isPartOf | EXPERIMENTAL DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Chemokine CCL17/metabolism | - |
dc.subject.MESH | Chemokine CCL22/metabolism | - |
dc.subject.MESH | Chemokines, CC/metabolism | - |
dc.subject.MESH | Corticotropin-Releasing Hormone/physiology* | - |
dc.subject.MESH | Dendritic Cells/metabolism* | - |
dc.subject.MESH | Dermatitis, Atopic/metabolism | - |
dc.subject.MESH | Dermatitis, Atopic/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-18/metabolism* | - |
dc.subject.MESH | Interleukin-6/metabolism | - |
dc.subject.MESH | Monocytes/metabolism* | - |
dc.subject.MESH | Protein Isoforms/metabolism | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Receptors, Corticotropin-Releasing Hormone/metabolism | - |
dc.title | Corticotropin-releasing factor decreases IL-18 in the monocyte-derived dendritic cell. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Hee Jung Lee | - |
dc.contributor.googleauthor | Yeon Sook Kwon | - |
dc.contributor.googleauthor | Chang Ook Park | - |
dc.contributor.googleauthor | Sang Ho Oh | - |
dc.contributor.googleauthor | Ju Hee Lee | - |
dc.contributor.googleauthor | Wen Hao Wu | - |
dc.contributor.googleauthor | Nam Soo Chang | - |
dc.contributor.googleauthor | Min-Geol Lee | - |
dc.contributor.googleauthor | Kwang Hoon Lee | - |
dc.identifier.doi | 10.1111/j.1600-0625.2008.00781.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02370 | - |
dc.contributor.localId | A02779 | - |
dc.contributor.localId | A03171 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J00866 | - |
dc.identifier.eissn | 1600-0625 | - |
dc.identifier.pmid | 18803662 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2008.00781.x/abstract | - |
dc.subject.keyword | atopic dermatitis | - |
dc.subject.keyword | corticotropin‐releasing factor | - |
dc.subject.keyword | dendritic cell | - |
dc.subject.keyword | IL‐18 | - |
dc.contributor.alternativeName | Lee, Ju Hee | - |
dc.contributor.alternativeName | Oh, Sang Ho | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.alternativeName | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Oh, Sang Ho | - |
dc.contributor.affiliatedAuthor | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Lee, Ju Hee | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.citation.volume | 18 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 204 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, Vol.18(3) : 199-204, 2009 | - |
dc.identifier.rimsid | 51683 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.