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Blood eicosapentaenoic acid and docosahexaenoic acid as predictors of all-cause mortality in patients with acute myocardial infarction--data from Infarction Prognosis Study (IPS) Registry

Authors
 Sang-Hak Lee  ;  Min-Jeong Shin  ;  Jung-Sun Kim  ;  Young-Guk Ko  ;  Seok-Min Kang  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Namsik Chung  ;  Won-Heum Shim  ;  Seung-Yun Cho  ;  Ichiro Manabe  ;  Jong-Won Ha 
Citation
 CIRCULATION JOURNAL, Vol.73(12) : 2250-2257, 2009 
Journal Title
 CIRCULATION JOURNAL 
ISSN
 1346-9843 
Issue Date
2009
MeSH
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Cause of Death ; Docosahexaenoic Acids/blood* ; Down-Regulation ; Eicosapentaenoic Acid/blood* ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Myocardial Infarction/blood* ; Myocardial Infarction/mortality* ; Predictive Value of Tests ; Proportional Hazards Models ; Prospective Studies ; Registries ; Renal Insufficiency/mortality ; Risk Assessment ; Risk Factors ; Sex Factors ; Time Factors
Keywords
Death ; Docosahexaenoic acid ; Eicosapentaenoic acid ; Myocardial infarction ; ω-3 fatty acids
Abstract
BACKGROUND: Although omega-3 polyunsaturated fatty acids are known to have beneficial effects on cardiovascular diseases, their prognostic value has not been studied prospectively in patients with acute myocardial infarction (AMI). METHODS AND RESULTS: The plasma levels of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (% of total fatty acids), were measured in 508 patients (365 males; mean age, 63 years) with AMI. Clinical and biomarker predictors of all-cause and cardiovascular mortality were identified by stepwise Cox regression model. During a mean follow-up of 16.1 months, 36 (7.1%) patients died. After controlling for confounding variables, age (hazard ratio (HR): 1.09, P<0.001), renal insufficiency (HR: 2.84, P=0.01) and EPA level (HR: 0.29, P=0.004) were identified as independent predictors of all cause-mortality. When stratified by gender, age (HR: 1.08, P=0.001) and renal insufficiency (HR: 4.49, P=0.003) were predictors of all-cause-mortality in males, whereas EPA level (HR: 0.18, P=0.009) and angiotensin-converting enzyme inhibitor use (HR: 0.24, P=0.03) were identified as predictive of all-cause-mortality in females. CONCLUSIONS: Lower plasma level of EPA, but not DHA, was an independent predictor for all-cause-mortality in patients with AMI, but this relationship was significant only in female patients.
Files in This Item:
T200903894.pdf Download
DOI
10.1253/circj.CJ-09-0327
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shim, Won Heum(심원흠)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Cho, Seung Yun(조승연)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105418
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