221 550

Cited 102 times in

Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents.

Authors
 J-S Kim  ;  I-K Jang  ;  J-S Kim  ;  T H Kim  ;  M Takano  ;  T Kume  ;  N W Hur  ;  Y-G Ko  ;  D Choi  ;  M-K Hong  ;  Y Jang 
Citation
 HEART, Vol.95(23) : 1907-1912, 2009 
Journal Title
HEART
ISSN
 1355-6037 
Issue Date
2009
MeSH
Coronary Stenosis/drug therapy* ; Coronary Stenosis/pathology ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Immunosuppressive Agents/administration & dosage* ; Male ; Middle Aged ; Observer Variation ; Sirolimus/administration & dosage* ; Sirolimus/analogs & derivatives* ; Tomography, Optical Coherence ; Treatment Outcome ; Tunica Intima/pathology
Abstract
OBJECTIVE: To evaluate the vascular response at 9 months after zotarolimus-eluting stent (ZES; Endeavor) implantation using optical coherence tomography (OCT). These findings were compared with those after implantation of a sirolimus-eluting stent (SES; Cypher Select).

DESIGN: Cross-sectional observational study with prospective OCT registry.

SETTING: Nine months after ZES or SES implantation.

PATIENTS AND METHODS: A total of 68 patients (32 ZES and 36 SES) underwent OCT at 9 months after stent implantation. The neointima hyperplasia (NIH) thickness inside each strut and percentage of NIH area at every 1 mm cross section were measured. Main outcome measurement: The degree of neointimal coverage and the prevalence of malapposition at 9 months after ZES and SES implantation using OCT.

RESULTS: The mean (SD) NIH thickness (251.2 (110.0) mum vs 85.5 (53.3) mum, p<0.001) and percentage of NIH area (27.9 (9.1)% vs 11.2 (7.1)%, p<0.001) were significantly greater in ZES than in SES. The prevalence of uncovered strut as well as malapposed strut was significantly lower in ZES than in SES (0.3% vs 12.3%, p<0.001 and 0.08% vs 2.6%, p<0.001). Thrombus was not observed in ZES (0.0% in ZES vs 27.8% in SES, p = 0.001).

CONCLUSIONS: Neointimal coverage in ZES was almost complete and malapposition was very rare at 9-months' follow-up.
Files in This Item:
T200903893.pdf Download
DOI
10.1136/hrt.2009.167759
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Kim, Jin Sun(김진선)
Kim, Tae-Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-4200-3456
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hur, Nam Wook(허남욱)
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105416
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links