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Predicting recurrence of nonfunctioning pituitary adenomas

Authors
 Tae-Woong Noh  ;  Hyeong Jae Jeong  ;  Mi-Kyung Lee  ;  Tai Seung Kim  ;  Sun Ho Kim  ;  Eun Jig Lee 
Citation
 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.94(11) : 4406-4413, 2009 
Journal Title
 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 
ISSN
 0021-972X 
Issue Date
2009
MeSH
Adenoma/pathology* ; Adenoma/surgery ; Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry/methods ; In Situ Nick-End Labeling/methods ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology* ; Pituitary Neoplasms/pathology* ; Pituitary Neoplasms/surgery ; Predictive Value of Tests ; Retrospective Studies ; Time Factors ; Young Adult
Abstract
CONTEXT: Nonfunctioning pituitary adenomas are commonly diagnosed as large tumors. Most are detected incidentally during imaging studies or as a result of neurological manifestations. Depending on severity, most patients with large tumors require surgery and adjunctive therapies because of the high rate of tumor recurrence. The ability to predict the recurrence of a tumor at the time of the initial surgery would be helpful in deciding whether adjunctive therapy is necessary and decreasing morbidity. We investigated the use of several cellular markers for predicting the recurrence of nonfunctioning pituitary adenomas. OBJECTIVE: A tissue array block was made using tissue from 35 cases of nonfunctioning pituitary adenomas (16 cases with early recurrence <or=4 yr after surgery, 10 cases with late recurrence >4 yr after surgery, and nine cases without recurrence). Levels of tumor tissue cellular markers associated with cell proliferation or apoptosis were analyzed, and immunohistochemical study of cellular markers was conducted using sectioned slides from the tissue array block. RESULTS: High Ki-67 and TUNEL labeling indexes were associated with recurrent nonfunctioning pituitary adenomas. Tumors with a high level of expression of phospho-Akt, phospho-p44/42 MAPK, and PTTG1 were associated with early recurrence. However, high levels of expression of phospho-CREB and ZAC1 were inversely associated with recurrence. CONCLUSIONS: Tumors with high levels of expression of phospho-Akt and phospho-p44/42 MAPK and low levels of expression of phospho-CREB and ZAC1 should be followed closely and may require adjunctive therapy to prevent tumor recurrence
Full Text
https://academic.oup.com/jcem/article/94/11/4406/2596742
DOI
10.1210/jc.2009-0471
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sun Ho(김선호) ORCID logo https://orcid.org/0000-0003-0970-3848
Kim, Tai Seung(김태승)
Noh, Tae Woong(노태웅)
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105381
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