0 290

Cited 54 times in

Predicting recurrence of nonfunctioning pituitary adenomas

DC FieldValueLanguage
dc.contributor.author김선호-
dc.contributor.author김태승-
dc.contributor.author이은직-
dc.contributor.author노태웅-
dc.date.accessioned2015-04-24T17:25:43Z-
dc.date.available2015-04-24T17:25:43Z-
dc.date.issued2009-
dc.identifier.issn0021-972X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105381-
dc.description.abstractCONTEXT: Nonfunctioning pituitary adenomas are commonly diagnosed as large tumors. Most are detected incidentally during imaging studies or as a result of neurological manifestations. Depending on severity, most patients with large tumors require surgery and adjunctive therapies because of the high rate of tumor recurrence. The ability to predict the recurrence of a tumor at the time of the initial surgery would be helpful in deciding whether adjunctive therapy is necessary and decreasing morbidity. We investigated the use of several cellular markers for predicting the recurrence of nonfunctioning pituitary adenomas. OBJECTIVE: A tissue array block was made using tissue from 35 cases of nonfunctioning pituitary adenomas (16 cases with early recurrence <or=4 yr after surgery, 10 cases with late recurrence >4 yr after surgery, and nine cases without recurrence). Levels of tumor tissue cellular markers associated with cell proliferation or apoptosis were analyzed, and immunohistochemical study of cellular markers was conducted using sectioned slides from the tissue array block. RESULTS: High Ki-67 and TUNEL labeling indexes were associated with recurrent nonfunctioning pituitary adenomas. Tumors with a high level of expression of phospho-Akt, phospho-p44/42 MAPK, and PTTG1 were associated with early recurrence. However, high levels of expression of phospho-CREB and ZAC1 were inversely associated with recurrence. CONCLUSIONS: Tumors with high levels of expression of phospho-Akt and phospho-p44/42 MAPK and low levels of expression of phospho-CREB and ZAC1 should be followed closely and may require adjunctive therapy to prevent tumor recurrence-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenoma/pathology*-
dc.subject.MESHAdenoma/surgery-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry/methods-
dc.subject.MESHIn Situ Nick-End Labeling/methods-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/epidemiology*-
dc.subject.MESHPituitary Neoplasms/pathology*-
dc.subject.MESHPituitary Neoplasms/surgery-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.subject.MESHYoung Adult-
dc.titlePredicting recurrence of nonfunctioning pituitary adenomas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorTae-Woong Noh-
dc.contributor.googleauthorHyeong Jae Jeong-
dc.contributor.googleauthorMi-Kyung Lee-
dc.contributor.googleauthorTai Seung Kim-
dc.contributor.googleauthorSun Ho Kim-
dc.contributor.googleauthorEun Jig Lee-
dc.identifier.doi10.1210/jc.2009-0471-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00560-
dc.contributor.localIdA01071-
dc.contributor.localIdA03050-
dc.contributor.localIdA02768-
dc.contributor.localIdA01299-
dc.relation.journalcodeJ01318-
dc.identifier.eissn1945-7197-
dc.identifier.pmid19820025-
dc.identifier.urlhttps://academic.oup.com/jcem/article/94/11/4406/2596742-
dc.contributor.alternativeNameKim, Sun Ho-
dc.contributor.alternativeNameKim, Tai Seung-
dc.contributor.alternativeNameNoh, Tae Woong-
dc.contributor.alternativeNameLee, Mi Kyung-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.affiliatedAuthorKim, Sun Ho-
dc.contributor.affiliatedAuthorKim, Tai Seung-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.contributor.affiliatedAuthorLee, Mi Kyung-
dc.contributor.affiliatedAuthorNoh, Tae Woong-
dc.citation.volume94-
dc.citation.number11-
dc.citation.startPage4406-
dc.citation.endPage4413-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.94(11) : 4406-4413, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.