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In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

Authors
 Wonkeun Song  ;  Borum Suh  ;  Jun Yong Choi  ;  Seok Hoon Jeong  ;  Eun Hee Jeon  ;  Young Ki Lee  ;  Seong Geun Hong  ;  Kyungwon Lee 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.65(4) : 447-449, 2009 
Journal Title
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
ISSN
 0732-8893 
Issue Date
2009
MeSH
Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use* ; Bacterial Proteins/genetics* ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Female ; Gene Deletion ; Humans ; Klebsiella Infections/drug therapy* ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/drug effects* ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/isolation & purification ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Plasmids ; Porins/genetics* ; Selection, Genetic* ; Sequence Analysis, DNA ; Thienamycins/therapeutic use* ; beta-Lactam Resistance*
Keywords
OmpK35 ; OmpK36 ; DHA-1 ; Carbapenems ; IS5
Abstract
We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC beta-lactamase
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889309003526
DOI
10.1016/j.diagmicrobio.2009.08.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105376
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