In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

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Authors: Wonkeun Song ; Borum Suh ; Jun Yong Choi ; Seok Hoon Jeong ; Eun Hee Jeon ; Young Ki Lee ; Seong Geun Hong ; Kyungwon Lee

Citation: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.65(4) : 447-449, 2009

MeSH: Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use* ; Bacterial Proteins/genetics* ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Female ; Gene Deletion ; Humans ; Klebsiella Infections/drug therapy* ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/drug effects* ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/isolation & purification ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Plasmids ; Porins/genetics* ; Selection, Genetic* ; Sequence Analysis, DNA ; Thienamycins/therapeutic use* ; beta-Lactam Resistance*

Abstract: We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC beta-lactamase

Full Text: http://www.sciencedirect.com/science/article/pii/S0732889309003526

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

Yonsei Authors: Lee, Kyungwon(이경원) https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) https://orcid.org/0000-0001-9290-897X
Choi, Jun Yong(최준용) https://orcid.org/0000-0002-2775-3315

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