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The effect of moesin overexpression on ageing of human dermal microvascular endothelial cells

Authors
 Ju Hee Lee  ;  In Ae Hong  ;  Sang Ho Oh  ;  Yeon Sook Kwon  ;  Soo Hyun Cho  ;  Kwang Hoon Lee 
Citation
 EXPERIMENTAL DERMATOLOGY, Vol.18(11) : 997-999, 2009 
Journal Title
 EXPERIMENTAL DERMATOLOGY 
ISSN
 0906-6705 
Issue Date
2009
MeSH
Aging ; Cell Cycle ; Cells, Cultured ; Cellular Senescence ; Cytoskeleton/metabolism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism* ; Gene Expression Regulation* ; Humans ; Microcirculation ; Microfilament Proteins/biosynthesis* ; Microfilament Proteins/metabolism ; Microscopy, Fluorescence/methods ; Microscopy, Phase-Contrast/methods ; Models, Biological ; RNA, Messenger/metabolism ; Skin/metabolism*
Keywords
ageing ; endothelial cell ; overexpression ; moesin
Abstract
Senescence of microvascular endothelial cells is known to play an important role in the pathophysiology of vascular diseases related to ageing, but the accurate mechanism or related genes are not known. Moesin, a cytoskeletal protein and the most potent candidate as an ageing-related protein, showed obvious changes in expression when compared before and after ageing. In this study, a lentivirus was used to overexpress moesin in endothelial cells. The expression of cell cycle mediators such as p16, cyclin D1 and cdk4, which can be the markers of ageing, was compared by RNA and was shown to be suppressed in moesin overexpressed endothelial cells. In conclusion, it can be said that the expression of moesin delays senescence of human dermal microvascular endothelial cells and this fundamental discovery can be used as a basis for understanding the mechanism of ageing and age-related diseases.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2009.00898.x/abstract
DOI
10.1111/j.1600-0625.2009.00898.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Kwang Hoon(이광훈)
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105369
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