Cited 5 times in
The effect of moesin overexpression on ageing of human dermal microvascular endothelial cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오상호 | - |
dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이주희 | - |
dc.date.accessioned | 2015-04-24T17:25:19Z | - |
dc.date.available | 2015-04-24T17:25:19Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105369 | - |
dc.description.abstract | Senescence of microvascular endothelial cells is known to play an important role in the pathophysiology of vascular diseases related to ageing, but the accurate mechanism or related genes are not known. Moesin, a cytoskeletal protein and the most potent candidate as an ageing-related protein, showed obvious changes in expression when compared before and after ageing. In this study, a lentivirus was used to overexpress moesin in endothelial cells. The expression of cell cycle mediators such as p16, cyclin D1 and cdk4, which can be the markers of ageing, was compared by RNA and was shown to be suppressed in moesin overexpressed endothelial cells. In conclusion, it can be said that the expression of moesin delays senescence of human dermal microvascular endothelial cells and this fundamental discovery can be used as a basis for understanding the mechanism of ageing and age-related diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 997~999 | - |
dc.relation.isPartOf | EXPERIMENTAL DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aging | - |
dc.subject.MESH | Cell Cycle | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Cellular Senescence | - |
dc.subject.MESH | Cytoskeleton/metabolism | - |
dc.subject.MESH | Endothelium, Vascular/cytology | - |
dc.subject.MESH | Endothelium, Vascular/metabolism* | - |
dc.subject.MESH | Gene Expression Regulation* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Microcirculation | - |
dc.subject.MESH | Microfilament Proteins/biosynthesis* | - |
dc.subject.MESH | Microfilament Proteins/metabolism | - |
dc.subject.MESH | Microscopy, Fluorescence/methods | - |
dc.subject.MESH | Microscopy, Phase-Contrast/methods | - |
dc.subject.MESH | Models, Biological | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Skin/metabolism* | - |
dc.title | The effect of moesin overexpression on ageing of human dermal microvascular endothelial cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Ju Hee Lee | - |
dc.contributor.googleauthor | In Ae Hong | - |
dc.contributor.googleauthor | Sang Ho Oh | - |
dc.contributor.googleauthor | Yeon Sook Kwon | - |
dc.contributor.googleauthor | Soo Hyun Cho | - |
dc.contributor.googleauthor | Kwang Hoon Lee | - |
dc.identifier.doi | 10.1111/j.1600-0625.2009.00898.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02370 | - |
dc.contributor.localId | A03171 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J00866 | - |
dc.identifier.eissn | 1600-0625 | - |
dc.identifier.pmid | 19555429 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2009.00898.x/abstract | - |
dc.subject.keyword | ageing | - |
dc.subject.keyword | endothelial cell | - |
dc.subject.keyword | overexpression | - |
dc.subject.keyword | moesin | - |
dc.contributor.alternativeName | Oh, Sang Ho | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.alternativeName | Lee, Ju Hee | - |
dc.contributor.affiliatedAuthor | Oh, Sang Ho | - |
dc.contributor.affiliatedAuthor | Lee, Ju Hee | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.citation.volume | 18 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 997 | - |
dc.citation.endPage | 999 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, Vol.18(11) : 997-999, 2009 | - |
dc.identifier.rimsid | 51639 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.