Cited 331 times in
Multifunctional nanoparticles for combined doxorubicin and photothermal treatments
DC Field | Value | Language |
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dc.contributor.author | 양재문 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2015-04-24T17:23:09Z | - |
dc.date.available | 2015-04-24T17:23:09Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105301 | - |
dc.description.abstract | To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2919~2926 | - |
dc.relation.isPartOf | ACS NANO | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/chemistry* | - |
dc.subject.MESH | Antineoplastic Agents/metabolism | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use | - |
dc.subject.MESH | Biocompatible Materials/chemistry | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Cell Survival/radiation effects | - |
dc.subject.MESH | Doxorubicin/chemistry* | - |
dc.subject.MESH | Doxorubicin/metabolism | - |
dc.subject.MESH | Doxorubicin/pharmacology | - |
dc.subject.MESH | Doxorubicin/therapeutic use | - |
dc.subject.MESH | Drug Carriers/chemistry* | - |
dc.subject.MESH | Gold/chemistry | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperthermia, Induced* | - |
dc.subject.MESH | Infrared Rays/therapeutic use | - |
dc.subject.MESH | Lactic Acid/chemistry | - |
dc.subject.MESH | Metal Nanoparticles/chemistry* | - |
dc.subject.MESH | Microscopy, Fluorescence | - |
dc.subject.MESH | Nanomedicine/methods* | - |
dc.subject.MESH | Phototherapy* | - |
dc.subject.MESH | Polyglycolic Acid/chemistry | - |
dc.title | Multifunctional nanoparticles for combined doxorubicin and photothermal treatments | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Huiyul Park | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Jaemin Lee | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.contributor.googleauthor | In-Hong Choi | - |
dc.contributor.googleauthor | Kyung-Hwa Yoo | - |
dc.identifier.doi | 10.1021/nn900215k | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04167 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J00005 | - |
dc.identifier.eissn | 1936-086X | - |
dc.identifier.pmid | 19772302 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/nn900215k | - |
dc.subject.keyword | chemo-photothermal treatment | - |
dc.subject.keyword | doxorubicin | - |
dc.subject.keyword | NIR resonance | - |
dc.subject.keyword | synergistic effect | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.citation.volume | 3 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2919 | - |
dc.citation.endPage | 2926 | - |
dc.identifier.bibliographicCitation | ACS NANO, Vol.3(10) : 2919-2926, 2009 | - |
dc.identifier.rimsid | 54289 | - |
dc.type.rims | ART | - |
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