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Urinary TGF-beta1 as an indicator of antiproteinuric response to angiotensin II receptor blocker in proteinuric renal diseases

 Hyeong Cheon Park  ;  Hoon Young Choi  ;  Beom Seok Kim  ;  Hye Rim An  ;  Jae Sung Lee  ;  Sung Kyu Ha  ;  Dae Suk Han 
 BIOMEDICINE & PHARMACOTHERAPY, Vol.63(9) : 672-678, 2009 
Journal Title
Issue Date
Adult ; Angiotensin II Type 1 Receptor Blockers/therapeutic use* ; Blood Pressure/drug effects ; Female ; Humans ; Losartan/therapeutic use* ; Male ; Middle Aged ; Proteinuria/drug therapy* ; Proteinuria/urine ; Transforming Growth Factor beta1/urine*
Losartan ; Proteinuria ; Urinary transforming growth factor-β1
BACKGROUND: Angiotensin II receptor blockers (ARBs) reduce proteinuria, however, with large inter-individual variability. The present study investigated whether urinary transforming growth factor-beta1 (TGF-beta1) might predict the antiproteinuric efficacy of ARB in non-diabetic chronic renal disease. METHODS: Non-diabetic patients with proteinuria (>1 g/day) received 50 mg of losartan daily followed by 100 mg in two treatment periods, each lasting 12 weeks. Clinical parameters and urinary TGF-beta1 levels were measured at baseline and during the treatment period. RESULTS: In the whole group of patients, losartan treatment effectively decreased proteinuria. However, considerable differences existed among individual antiproteinuric responses. Good (n=34) or low (n=15) responders showed average proteinuria reduction of 69% or 17% from baseline, respectively. Both groups showed similar baseline biochemical and renal parameters and comparable degree of mean arterial blood pressure (MAP) reduction. However, the low responders were older and showed significantly higher baseline urinary TGF-beta1 levels. On multiple regression analysis, age, baseline urinary TGF-beta1 and % reduction in urinary TGF-beta1 and % reduction in MAP significantly predicted antiproteinuric response to losartan therapy. CONCLUSION: The present data suggest that the determination of baseline urinary TGF-beta1 could be an useful indicator of short-term antiproteinuric response to ARB treatment in non-diabetic nephropathy.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Park, Hyeong Cheon(박형천) ORCID logo https://orcid.org/0000-0002-1550-0812
Ha, Sung Kyu(하성규)
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