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천식 환아에서 호기산화질소(exhaled nitric oxide)와 폐기능 및 기도과민성의 연관성

Other Titles
 Relationship between Exhaled Nitric Oxide Concentration and Pulmonary Function/Airway Hyperresponsiveness in Asthmatic Children 
 최봉석  ;  지혜미  ;  박여훈  ;  김경원  ;  손명현  ;  김규언 
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.19(3) : 291-299, 2009 
Journal Title
Pediatric Allergy and Respiratory Disease(소아알레르기 호흡기학회지)
Issue Date
Nitric oxide ; Asthma ; Children ; Spirometry ; Bronchial hyperactivity ; Impulse oscillometry
Purpose: Exhaled nitric oxide (eNO) has been proposed as a non-invasive marker for airway inflammation in asthma. Pulmonary function tests have been widely used in the diagnosis and management of asthma. Airway hyperresponsiveness (AHR) is one of the major features in asthma and usually assessed by the methacholine challenge test. The purpose of the present study was to assess the possible relationship between eNO and pulmonary function/AHR in asthmatic children. Methods: There were 121 asthmatic children and 81 controls in the study. The eNO level was measured, the methacholline challenge test, spirometry, impulse oscillometry (IOS) and assessment of their bronchodilator responses were performed on all subjects. Results: The asthma group had a higher eNO value than the control group [28.3 (15-55.75) vs. 20 (12.35-39.7) ppb, P=0.015]. The eNO level correlated positively with dFEV1 (r=0.230, P=0.001). It correlate inversely with dR5 (r=-0.149, P=0.036), eNO with PC20 (r=-0.318, P<0.001) and with FEF25-75 (r=-0.17, P=0.015), but not with FEV1. Conclusion: This study suggests that eNO values may reflect AHR, as well as airway inflammation, but not pulmonary function
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Choi, Bong Seok(최봉석)
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