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천식 환아에서 호기산화질소(exhaled nitric oxide)와 폐기능 및 기도과민성의 연관성

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dc.contributor.author김경원-
dc.contributor.author김규언-
dc.contributor.author손명현-
dc.contributor.author최봉석-
dc.date.accessioned2015-04-24T17:17:03Z-
dc.date.available2015-04-24T17:17:03Z-
dc.date.issued2009-
dc.identifier.issn1225-679X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105105-
dc.description.abstractPurpose: Exhaled nitric oxide (eNO) has been proposed as a non-invasive marker for airway inflammation in asthma. Pulmonary function tests have been widely used in the diagnosis and management of asthma. Airway hyperresponsiveness (AHR) is one of the major features in asthma and usually assessed by the methacholine challenge test. The purpose of the present study was to assess the possible relationship between eNO and pulmonary function/AHR in asthmatic children. Methods: There were 121 asthmatic children and 81 controls in the study. The eNO level was measured, the methacholline challenge test, spirometry, impulse oscillometry (IOS) and assessment of their bronchodilator responses were performed on all subjects. Results: The asthma group had a higher eNO value than the control group [28.3 (15-55.75) vs. 20 (12.35-39.7) ppb, P=0.015]. The eNO level correlated positively with dFEV1 (r=0.230, P=0.001). It correlate inversely with dR5 (r=-0.149, P=0.036), eNO with PC20 (r=-0.318, P<0.001) and with FEF25-75 (r=-0.17, P=0.015), but not with FEV1. Conclusion: This study suggests that eNO values may reflect AHR, as well as airway inflammation, but not pulmonary function-
dc.description.statementOfResponsibilityopen-
dc.format.extent291~299-
dc.relation.isPartOfPediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title천식 환아에서 호기산화질소(exhaled nitric oxide)와 폐기능 및 기도과민성의 연관성-
dc.title.alternativeRelationship between Exhaled Nitric Oxide Concentration and Pulmonary Function/Airway Hyperresponsiveness in Asthmatic Children-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthor최봉석-
dc.contributor.googleauthor지혜미-
dc.contributor.googleauthor박여훈-
dc.contributor.googleauthor김경원-
dc.contributor.googleauthor손명현-
dc.contributor.googleauthor김규언-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00303-
dc.contributor.localIdA00327-
dc.contributor.localIdA01967-
dc.contributor.localIdA04064-
dc.relation.journalcodeJ02476-
dc.subject.keywordNitric oxide-
dc.subject.keywordAsthma-
dc.subject.keywordChildren-
dc.subject.keywordSpirometry-
dc.subject.keywordBronchial hyperactivity-
dc.subject.keywordImpulse oscillometry-
dc.contributor.alternativeNameKim, Kyung Won-
dc.contributor.alternativeNameKim, Kyu Earn-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.alternativeNameChoi, Bong Seok-
dc.contributor.affiliatedAuthorKim, Kyung Won-
dc.contributor.affiliatedAuthorKim, Kyu Earn-
dc.contributor.affiliatedAuthorSon, Myung Hyun-
dc.contributor.affiliatedAuthorChoi, Bong Seok-
dc.citation.volume19-
dc.citation.number3-
dc.citation.startPage291-
dc.citation.endPage299-
dc.identifier.bibliographicCitationPediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.19(3) : 291-299, 2009-
dc.identifier.rimsid56751-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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