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Manganese-Enhanced Magnetic Resonance Imaging of the Spinal Cord in Rats

Authors
 Myeoung Hoon Cha  ;  Chulhyun Lee  ;  Jee Hyun Cho  ;  Myung-Ae Chung  ;  Jin-Hun Sohn  ;  Chaejoon Cheong  ;  Hye-Jung Lee  ;  Bae Hwan Lee 
Citation
 EXPERIMENTAL NEUROBIOLOGY, Vol.18(1) : 57-61, 2009 
Journal Title
EXPERIMENTAL NEUROBIOLOGY
ISSN
 1226-2560 
Issue Date
2009
Keywords
manganese ; magnetic resonance imaging ; spinal cord ; rat
Abstract
Manganese-enhanced magnetic resonance imaging (MEMRI) offers a novel neuroimaging
method in visualizing the activity patterns of neural circuits. MEMRI is using
the divalent manganese ion, which has been used as a cellular contrast agent. The
present study was conducted to determine the contrast-enhancing effects of manganese
ion administered into the spinal cord of rats. Manganese ion was administered
into the spinal cord by lumbar puncture. Ex vivo magnetic resonance images were
obtained at 6, 12, 24, and 48 hours after manganese ion injection. Although the highly
contrasted images were not observed 6 or 12 hr after manganese injection, the
distinctive manganese-enhanced images began to appear at 24 hours after manganese
ion injection. These results suggest that the gray matter is the foci of intense
paramagnetic signals and MEMRI may provide an effective technique to visualize the
activity-dependent patterns in the spinal cord
Files in This Item:
T200903490.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Cha, Myeoung Hoon(차명훈) ORCID logo https://orcid.org/0000-0002-7993-672X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105090
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