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Genetic mutation of transforming growth factor beta type II receptor in oral squamous cell carcinoma

Authors
 Eun Ha Lee  ;  Kyung Jin Bae  ;  Tae Kyu Kim  ;  Hye-Seo Park  ;  Eun Ju Lee  ;  Jin Kim 
Citation
 Basic and Applied Pathology, Vol.2(3) : 82-88, 2009 
Journal Title
 Basic and Applied Pathology 
ISSN
 1755-9294 
Issue Date
2009
Keywords
mutations ; oral squamous cell carcinoma ; SNP ; TGFβ1 type II receptor
Abstract
Background and aim: The deregulation of transforming growth factor β (TGF-β) action and its signaling function has been a widely accepted concept in carcinogenesis. However, its dual roles, as a tumor suppressor gene and oncogene, have interfered in applying TGF-β signaling to cancer therapeutics. To evaluate its role in the carcinogenesis of oral squamous cell carcinoma (OSCC), we performed mutational analysis of the TGF-β type II receptor (TβRII). Methods: Eighteen cases of OSCC were used for mutational analysis of TβRII. Normal surgical margin, dysplastic lesion, invasive carcinoma and metastatic cancer cells into lymph node tissue were used. Exon-specific spanning primers of exon 1, 2, 3, 4, 5, 6, 7 of TβRII were used for the mutational analysis. Results: A single nucleotide polymorphism (SNP) at the codon 191 was found in 8 cases. The genetic mutations were mainly found in exon 4 through dysplastic areas, carcinoma and metastatic areas, which induced the structural change or the alteration of hydrophobicity of the amino acid. Conclusions:TβRII mutations occur frequently in exon 4 in OSCC and their functional significance should be proven
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1755-9294.2009.01046.x/abstract
DOI
10.1111/j.1755-9294.2009.01046.x
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Kim, Tae Kyu(김태규)
Lee, Eun Ha(이은하)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105019
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