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Genetic mutation of transforming growth factor beta type II receptor in oral squamous cell carcinoma

DC FieldValueLanguage
dc.contributor.author이은하-
dc.contributor.author김진-
dc.contributor.author김태규-
dc.date.accessioned2015-04-24T17:14:25Z-
dc.date.available2015-04-24T17:14:25Z-
dc.date.issued2009-
dc.identifier.issn1755-9294-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105019-
dc.description.abstractBackground and aim: The deregulation of transforming growth factor β (TGF-β) action and its signaling function has been a widely accepted concept in carcinogenesis. However, its dual roles, as a tumor suppressor gene and oncogene, have interfered in applying TGF-β signaling to cancer therapeutics. To evaluate its role in the carcinogenesis of oral squamous cell carcinoma (OSCC), we performed mutational analysis of the TGF-β type II receptor (TβRII). Methods: Eighteen cases of OSCC were used for mutational analysis of TβRII. Normal surgical margin, dysplastic lesion, invasive carcinoma and metastatic cancer cells into lymph node tissue were used. Exon-specific spanning primers of exon 1, 2, 3, 4, 5, 6, 7 of TβRII were used for the mutational analysis. Results: A single nucleotide polymorphism (SNP) at the codon 191 was found in 8 cases. The genetic mutations were mainly found in exon 4 through dysplastic areas, carcinoma and metastatic areas, which induced the structural change or the alteration of hydrophobicity of the amino acid. Conclusions:TβRII mutations occur frequently in exon 4 in OSCC and their functional significance should be proven-
dc.description.statementOfResponsibilityopen-
dc.format.extent82~88-
dc.relation.isPartOfBasic and Applied Pathology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleGenetic mutation of transforming growth factor beta type II receptor in oral squamous cell carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학)-
dc.contributor.googleauthorEun Ha Lee-
dc.contributor.googleauthorKyung Jin Bae-
dc.contributor.googleauthorTae Kyu Kim-
dc.contributor.googleauthorHye-Seo Park-
dc.contributor.googleauthorEun Ju Lee-
dc.contributor.googleauthorJin Kim-
dc.identifier.doi10.1111/j.1755-9294.2009.01046.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03051-
dc.contributor.localIdA01066-
dc.contributor.localIdA01009-
dc.relation.journalcodeJ00272-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1755-9294.2009.01046.x/abstract-
dc.subject.keywordmutations-
dc.subject.keywordoral squamous cell carcinoma-
dc.subject.keywordSNP-
dc.subject.keywordTGFβ1 type II receptor-
dc.contributor.alternativeNameLee, Eun Ha-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.alternativeNameKim, Tae Kyu-
dc.contributor.affiliatedAuthorLee, Eun Ha-
dc.contributor.affiliatedAuthorKim, Tae Kyu-
dc.contributor.affiliatedAuthorKim, Jin-
dc.citation.volume2-
dc.citation.number3-
dc.citation.startPage82-
dc.citation.endPage88-
dc.identifier.bibliographicCitationBasic and Applied Pathology, Vol.2(3) : 82-88, 2009-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

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