Cited 3 times in
Genetic mutation of transforming growth factor beta type II receptor in oral squamous cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | 이은하 | - |
dc.contributor.author | 김진 | - |
dc.contributor.author | 김태규 | - |
dc.date.accessioned | 2015-04-24T17:14:25Z | - |
dc.date.available | 2015-04-24T17:14:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1755-9294 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105019 | - |
dc.description.abstract | Background and aim: The deregulation of transforming growth factor β (TGF-β) action and its signaling function has been a widely accepted concept in carcinogenesis. However, its dual roles, as a tumor suppressor gene and oncogene, have interfered in applying TGF-β signaling to cancer therapeutics. To evaluate its role in the carcinogenesis of oral squamous cell carcinoma (OSCC), we performed mutational analysis of the TGF-β type II receptor (TβRII). Methods: Eighteen cases of OSCC were used for mutational analysis of TβRII. Normal surgical margin, dysplastic lesion, invasive carcinoma and metastatic cancer cells into lymph node tissue were used. Exon-specific spanning primers of exon 1, 2, 3, 4, 5, 6, 7 of TβRII were used for the mutational analysis. Results: A single nucleotide polymorphism (SNP) at the codon 191 was found in 8 cases. The genetic mutations were mainly found in exon 4 through dysplastic areas, carcinoma and metastatic areas, which induced the structural change or the alteration of hydrophobicity of the amino acid. Conclusions:TβRII mutations occur frequently in exon 4 in OSCC and their functional significance should be proven | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 82~88 | - |
dc.relation.isPartOf | Basic and Applied Pathology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Genetic mutation of transforming growth factor beta type II receptor in oral squamous cell carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학) | - |
dc.contributor.googleauthor | Eun Ha Lee | - |
dc.contributor.googleauthor | Kyung Jin Bae | - |
dc.contributor.googleauthor | Tae Kyu Kim | - |
dc.contributor.googleauthor | Hye-Seo Park | - |
dc.contributor.googleauthor | Eun Ju Lee | - |
dc.contributor.googleauthor | Jin Kim | - |
dc.identifier.doi | 10.1111/j.1755-9294.2009.01046.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03051 | - |
dc.contributor.localId | A01066 | - |
dc.contributor.localId | A01009 | - |
dc.relation.journalcode | J00272 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1755-9294.2009.01046.x/abstract | - |
dc.subject.keyword | mutations | - |
dc.subject.keyword | oral squamous cell carcinoma | - |
dc.subject.keyword | SNP | - |
dc.subject.keyword | TGFβ1 type II receptor | - |
dc.contributor.alternativeName | Lee, Eun Ha | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.alternativeName | Kim, Tae Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Eun Ha | - |
dc.contributor.affiliatedAuthor | Kim, Tae Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.citation.volume | 2 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 82 | - |
dc.citation.endPage | 88 | - |
dc.identifier.bibliographicCitation | Basic and Applied Pathology, Vol.2(3) : 82-88, 2009 | - |
dc.identifier.rimsid | 55152 | - |
dc.type.rims | ART | - |
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