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인공 초기우식병소에 대한 나노크기 탄산인회석의 재광화 효과

Other Titles
 The effect of nano-sized carbonate apatite on remineralization of artificial caries-Like Lesions 
 김영숙  ;  민지현  ;  김영석  ;  홍석진  ;  권호근  ;  김백일 
 Journal of Korean Academy of Oral Health (대한구강보건학회지), Vol.33(1) : 40-50, 2009 
Journal Title
Journal of Korean Academy of Oral Health(대한구강보건학회지)
Issue Date
Casein phosphopeptide-amorphous calcium phosphate ; Carbonate apatite ; Dental caries ; Nano ; Remineralization
Objectives: The purpose of this study was to evaluate the remineralization effects of nano-sized carbonate apatite (n-CAP) paste and to compare it with casein phosphopeptide amorphous-calcium phosphate (CPP-ACP) paste.

Methods: The bovine enamel specimens formed artificial caries were randomly divided into 4 groups: (1) 0% n-CAP (negative control group), (2) 5% n-CAP (first experimental group), (3) 10% n-CAP (second experimental group), (4) Tooth MousseTM (TM, positive control group) containing 10% CPP-ACP. We compared the remineralization effects of n-CAP and CPP-ACP on early caries lesions using the pH-cycling model for 14 days. All specimens were evaluated surface hardness by Vickers Hardness Number (VHN) at before and after pH-cycling. The degree of mineral loss (volume% mineral) was measured as ΔZ (total mineral loss) using the Knoop Hardness Number (KHN) to determine the remineralization effect by lesion depth. Scanning Electron Microscope (SEM) to examine the features of remineralization on the specimen surface. The results were analyzed with one-way ANOVA using SPSS 12.0 statistical package program (SPSS Inc, USA).

Results: On observing changes in the surface microhardness, 5% n-CAP group had much higher ΔVHN (23.16±9.99) than did the other groups. On measuring the mineral loss by depth of enamel lesions, TM groups exhibited lower ΔZ, total mineral loss (1014.9±342.8) from KHN than the other groups. The features of the enamel surfaces were observed using SEM. The surface of 10% n-CAP group was not only covered with nano-sized particles but also regular and flat. On the other hand, the surface of TM group was irregular.

Conclusion: 5% n-CAP had the effect of remineralization on the enamel surface layer, so it is possible to use n-CAP for remineralization of dental erosion.
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2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ho Keun(권호근)
Kim, Baek Il(김백일) ORCID logo https://orcid.org/0000-0001-8234-2327
Kim, Young Seok(김영석)
Min, Ji Hyun(민지현)
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