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Bone mineral density, arterial stiffness, and coronary atherosclerosis in healthy postmenopausal women

Authors
 Seok Kyo Seo  ;  SiHyun Cho  ;  Hye Yeon Kim  ;  Young Sik Choi  ;  Ki Hyun Park  ;  Dong Jae Cho  ;  Byung Seok Lee 
Citation
 MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol.16(5) : 937-943, 2009 
Journal Title
 MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 
ISSN
 1072-3714 
Issue Date
2009
MeSH
Absorptiometry, Photon/methods ; Absorptiometry, Photon/standards ; Analysis of Variance ; Ankle Brachial Index/methods* ; Ankle Brachial Index/standards ; Bone Density/physiology* ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology* ; Female ; Femur/diagnostic imaging ; Humans ; Korea/epidemiology ; Logistic Models ; Lumbar Vertebrae/diagnostic imaging ; Mass Screening/methods* ; Mass Screening/standards ; Osteoporosis, Postmenopausal/complications ; Osteoporosis, Postmenopausal/diagnostic imaging ; Osteoporosis, Postmenopausal/epidemiology* ; Postmenopause/physiology* ; Retrospective Studies ; Risk Factors ; Sensitivity and Specificity ; Tomography, X-Ray Computed/methods ; Tomography, X-Ray Computed/standards ; Vascular Resistance/physiology
Keywords
Bone mineral density ; Arterial stiffness ; Coronary atherosclerosis ; Postmenopausal women
Abstract
OBJECTIVE: The aim of this study was to assess the correlation between bone mineral density (BMD), arterial stiffness, and coronary atherosclerosis in healthy postmenopausal women. METHODS: We performed a retrospective review of 152 postmenopausal women who visited the health promotion center for a routine checkup, after excluding participants who had factors affecting BMD and coronary artery disease. BMD was evaluated by dual-energy x-ray absorptiometry in the lumbar spine and femur. Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV), and coronary atherosclerosis was assessed by 64-row multidetector computed tomography. RESULTS: Women with osteoporosis had a significantly higher baPWV than those in the osteopenia and normal BMD groups. Higher baPWV was also associated with the presence of atherosclerosis. The baPWV was significantly positively correlated with age, systolic blood pressure, diastolic blood pressure, and neutrophil to lymphocyte ratio and negatively correlated with femur BMD. The optimum predictive value of baPWV in coronary atherosclerosis was estimated using the receiver operating characteristic curve. A cutoff of 1,506 cm/second would give a sensitivity of 83.3% and specificity of 82.9%. A higher overall risk for coronary atherosclerosis emerges with higher baPWV levels (>1,500 cm/s) after controlling for age and cardiovascular risk factors. CONCLUSIONS: Arterial stiffness by measuring baPWV can be a useful independent predictor for coronary atherosclerosis. In addition, our results suggest that postmenopausal women with osteoporosis should be considered for further evaluation of coronary atherosclerosis
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042192-200916050-00018&LSLINK=80&D=ovft
DOI
10.1097/gme.0b013e3181a15552
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Yeon(김혜연)
Park, Ki Hyun(박기현)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Cho, Dong Je(조동제)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104935
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