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Incremental predictive value of pre-procedural N-terminal pro-B-type natriuretic peptide for short-term recurrence in atrial fibrillation ablation

Authors
 Hye Jin Hwang  ;  Jung Woo Son  ;  Byung-Ho Nam  ;  Boyoung Joung  ;  Byungho Lee  ;  Jin-Bae Kim  ;  Moon-Hyoung Lee  ;  Yangsoo Jang  ;  Namsik Chung  ;  Won-Heum Shim  ;  Seung-Yun Cho  ;  Sung Soon Kim 
Citation
 Clinical Research in Cardiology, Vol.98(4) : 213-218, 2009 
Journal Title
 Clinical Research in Cardiology 
ISSN
 1861-0684 
Issue Date
2009
MeSH
Adult ; Aged ; Atrial Fibrillation/blood ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/therapy* ; Biomarkers/blood ; Catheter Ablation/methods* ; Echocardiography ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood* ; Peptide Fragments/blood* ; Predictive Value of Tests ; Prospective Studies ; Recurrence ; Risk Factors ; Ventricular Function, Left
Keywords
atrial fibrillation ; catheter ablation ; NT-proBNP
Abstract
The objective of this work was to assess the predictive value of pre-procedural N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients undergoing atrial fibrillation (AF) ablation. Seventy-three consecutive patients with AF (paroxysmal n = 49, persistent n = 24) and preserved left ventricular (LV) systolic function (LV ejection fraction > 45%) were prospectively enrolled in this study. All of the enrolled patients underwent catheter ablation after a measurement of their plasma NT-proBNP levels, and an echocardiographic examination with assessment of their LV diastolic function and left atrial(LA) volume. Patients with AF recurrence at 3 months had more persistent AF (P = 0.001), a higher LA volume index (P = 0.002), lesser decelerating times (DT) of mitral inflow (P = 0.014), and higher NT-proBNP levels (P < 0.001), when compared with patients with sinus rhythm restoration. The baseline log NT-proBNP correlated significantly with age (r = 0.26, P = 0.025), LA volume index (r = 0.41, P = 0.001), E/E' (r = 0.34, P = 0.007), DT (r = -0.34, P = 0.007), and E (r = 0.25, P = 0.04). The log NT-proBNP (HR 7.76, 95% CI 2.95-20.39, P < 0.001) was an independent predictor of AF recurrence. The measurement of NT-proBNP added incremental predictive value to standard indexes of LA size or diastolic function, including LA volume index and DT (P = 0.02). This study suggests the clinical utility of the level of NT-proBNP as an integrating marker of various risk factors, and as an incremental predictive marker for AF catheter ablation.
Full Text
http://link.springer.com/article/10.1007%2Fs00392-009-0744-3
DOI
10.1007/s00392-009-0744-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soon(김성순)
Kim, Jin Bae(김진배)
Son, Jung Woo(손정우)
Shim, Won Heum(심원흠)
Lee, Moon Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Lee, Byung Ho(이병호)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
Cho, Seung Yun(조승연)
Hwang, Hye Jin(황혜진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104890
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