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Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model

 Sang Tae Choi  ;  Ji Hye Kim  ;  Jae-Yeon Seok  ;  Yong-Beom Park  ;  Soo-Kon Lee 
 CLINICAL RHEUMATOLOGY, Vol.28(3) : 333-337, 2009 
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Animals ; Antibodies, Blocking/pharmacology* ; Antibodies, Monoclonal/pharmacology* ; Arthritis, Experimental/pathology ; Arthritis, Experimental/physiopathology ; Arthritis, Experimental/therapy* ; Arthritis, Rheumatoid/pathology ; Arthritis, Rheumatoid/physiopathology ; Arthritis, Rheumatoid/therapy* ; Blood Vessels/drug effects ; Blood Vessels/pathology ; Hindlimb ; Joints/drug effects ; Joints/pathology ; Male ; Mice ; Mice, Inbred DBA ; Neovascularization, Pathologic/drug therapy ; Synovial Membrane/blood supply ; Vascular Endothelial Growth Factor Receptor-1/immunology*
Angiogenesis ; Anti-VEGF RI antibody ; Collagen-induced arthritis ; Rheumatoid arthritis
Synovial angiogenesis plays an important role in the inflammation in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) is a key molecule in angiogenesis and binds to specific receptors, known as vascular endothelial growth factor receptor I (VEGF RI). In this study, we investigated the therapeutic efficacy of anti-VEGF RI antibody (Ab) on RA using a collagen-induced arthritis (CIA) mouse model. Twelve DBA/1 mice were divided into three groups. All mice except controls were injected with type II collagen. Mice in the anti-VEGF-RI-Ab-treated groups were injected on one posterior paw with 50 microg anti-VEGF RI Ab twice weekly for 3 weeks. Arthritis score and paw thickness were measured and histopathologic assessment of joint sections was performed by hematoxylin-eosin. The infiltration of CD45+ inflammatory cells and neovascularization were evaluated by immunohistochemical staining. Anti-VEGF RI Ab significantly attenuated the arthritis severity and histopathologic findings in the CIA mice model. The infiltration of CD45+ cells decreased in anti-VEGF-RI-Ab-treated joint tissues. Staining for CD31 revealed reduced synovial neovascularization after anti-VEGF RI Ab treatment. The data showing that in vivo administration of anti-VEGF RI Ab suppressed arthritis in established CIA mice suggest anti-VEGF RI Ab treatment may serve as a new therapeutic modality for RA.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Seok, Jae Yeon(석재연)
Lee, Soo Kon(이수곤)
Choi, Sang Tae(최상태)
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