Cited 39 times in
Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 석재연 | - |
dc.contributor.author | 이수곤 | - |
dc.contributor.author | 최상태 | - |
dc.date.accessioned | 2015-04-24T17:07:41Z | - |
dc.date.available | 2015-04-24T17:07:41Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0770-3198 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104813 | - |
dc.description.abstract | Synovial angiogenesis plays an important role in the inflammation in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) is a key molecule in angiogenesis and binds to specific receptors, known as vascular endothelial growth factor receptor I (VEGF RI). In this study, we investigated the therapeutic efficacy of anti-VEGF RI antibody (Ab) on RA using a collagen-induced arthritis (CIA) mouse model. Twelve DBA/1 mice were divided into three groups. All mice except controls were injected with type II collagen. Mice in the anti-VEGF-RI-Ab-treated groups were injected on one posterior paw with 50 microg anti-VEGF RI Ab twice weekly for 3 weeks. Arthritis score and paw thickness were measured and histopathologic assessment of joint sections was performed by hematoxylin-eosin. The infiltration of CD45+ inflammatory cells and neovascularization were evaluated by immunohistochemical staining. Anti-VEGF RI Ab significantly attenuated the arthritis severity and histopathologic findings in the CIA mice model. The infiltration of CD45+ cells decreased in anti-VEGF-RI-Ab-treated joint tissues. Staining for CD31 revealed reduced synovial neovascularization after anti-VEGF RI Ab treatment. The data showing that in vivo administration of anti-VEGF RI Ab suppressed arthritis in established CIA mice suggest anti-VEGF RI Ab treatment may serve as a new therapeutic modality for RA. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 333~337 | - |
dc.relation.isPartOf | CLINICAL RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Blocking/pharmacology* | - |
dc.subject.MESH | Antibodies, Monoclonal/pharmacology* | - |
dc.subject.MESH | Arthritis, Experimental/pathology | - |
dc.subject.MESH | Arthritis, Experimental/physiopathology | - |
dc.subject.MESH | Arthritis, Experimental/therapy* | - |
dc.subject.MESH | Arthritis, Rheumatoid/pathology | - |
dc.subject.MESH | Arthritis, Rheumatoid/physiopathology | - |
dc.subject.MESH | Arthritis, Rheumatoid/therapy* | - |
dc.subject.MESH | Blood Vessels/drug effects | - |
dc.subject.MESH | Blood Vessels/pathology | - |
dc.subject.MESH | Hindlimb | - |
dc.subject.MESH | Joints/drug effects | - |
dc.subject.MESH | Joints/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred DBA | - |
dc.subject.MESH | Neovascularization, Pathologic/drug therapy | - |
dc.subject.MESH | Synovial Membrane/blood supply | - |
dc.subject.MESH | Vascular Endothelial Growth Factor Receptor-1/immunology* | - |
dc.title | Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Sang Tae Choi | - |
dc.contributor.googleauthor | Ji Hye Kim | - |
dc.contributor.googleauthor | Jae-Yeon Seok | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Soo-Kon Lee | - |
dc.identifier.doi | 10.1007/s10067-008-1075-x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A01928 | - |
dc.contributor.localId | A02889 | - |
dc.contributor.localId | A04068 | - |
dc.relation.journalcode | J00612 | - |
dc.identifier.eissn | 1434-9949 | - |
dc.identifier.pmid | 19101756 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10067-008-1075-x | - |
dc.subject.keyword | Angiogenesis | - |
dc.subject.keyword | Anti-VEGF RI antibody | - |
dc.subject.keyword | Collagen-induced arthritis | - |
dc.subject.keyword | Rheumatoid arthritis | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Seok, Jae Yeon | - |
dc.contributor.alternativeName | Lee, Soo Kon | - |
dc.contributor.alternativeName | Choi, Sang Tae | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Seok, Jae Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Choi, Sang Tae | - |
dc.citation.volume | 28 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 333 | - |
dc.citation.endPage | 337 | - |
dc.identifier.bibliographicCitation | CLINICAL RHEUMATOLOGY, Vol.28(3) : 333-337, 2009 | - |
dc.identifier.rimsid | 41940 | - |
dc.type.rims | ART | - |
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