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The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma

Authors
 Jeong-Hee Choi  ;  Kyung-Wha Lee  ;  Cheol-Woo Kim  ;  Choon-Sik Park  ;  Hyun-Young Lee  ;  Gyu-Young Hur  ;  Seung-Hyun Kim  ;  Chein-Soo Hong  ;  An-Soo Jang  ;  Hae-Sim Park 
Citation
 INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Vol.150(2) : 156-163, 2009 
Journal Title
 INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 
ISSN
 1018-2438 
Issue Date
2009
MeSH
Adult ; Asthma/chemically induced* ; Asthma/genetics* ; Asthma/physiopathology ; Female ; Forced Expiratory Volume/physiology ; Gene Frequency/genetics ; HLA-DP Antigens/genetics* ; HLA-DP beta-Chains ; HLA-DQ Antigens/genetics* ; HLA-DQ beta-Chains ; HLA-DR Antigens/genetics* ; HLA-DRB1 Chains ; Haplotypes/genetics* ; Humans ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Korea ; Male ; Membrane Glycoproteins/genetics* ; Middle Aged ; Occupational Diseases/chemically induced ; Occupational Diseases/genetics* ; Occupational Diseases/immunology ; Risk Factors ; Toluene 2,4-Diisocyanate/adverse effects* ; Toluene 2,4-Diisocyanate/immunology
Keywords
Toluene diisocyanate ; Asthma ; Human leukocyte antigen class ; Immunoglobulin E
Abstract
BACKGROUND: Although the pathogenesis of toluene diisocyanate (TDI)-induced occupational asthma (TDI-OA) is incompletely understood, several studies have suggested immunologic mechanisms, including specific IgE responses. A few studies have suggested human leukocyte antigen (HLA) associations with TDI-induced asthma in Western countries, but this is the first investigation of associations between HLA class I and II alleles and TDI-induced asthma patients in Asia, using high-resolution analysis. METHODS: Patients with TDI-OA (n = 84), asymptomatic exposed controls (AECs, n = 47) and unexposed normal controls (NCs, n = 127) were enrolled. HLA class I and II genotyping was performed by the direct DNA sequencing analysis. Specific serum IgE antibodies to the vapor type TDI-albumin conjugate were measured by ELISA. RESULTS: There was no significant association between the allele frequencies and the phenotype of TDI-OA. However, the frequency of the HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype was significantly higher in TDI-OA patients (19%) than in AEC (2.1%, p = 0.007, OR 4.429, CI 1.497-13.103) or NC (3.1%, p < 0.001, OR 7.235, CI 2.236-22.510) subjects, with statistical significance persisting after correction for multiple comparisons. DQB1*0402 was significantly associated with the presence of specific IgE to TDI-albumin conjugates in serum (p = 0.006, OR 4.552, CI 1.540-13.449). This p value remained significant after correction for multiple comparison. CONCLUSION: The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype may be a genetic marker for the development of TDI-induced asthma in Koreans. Several HLA alleles that enhance specific IgE sensitization in exposed subjects are indicated.
Full Text
http://www.karger.com/Article/FullText/218118
DOI
10.1159/000218118
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104804
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