Cited 27 times in
The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma
DC Field | Value | Language |
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dc.contributor.author | 홍천수 | - |
dc.date.accessioned | 2015-04-24T17:07:25Z | - |
dc.date.available | 2015-04-24T17:07:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104804 | - |
dc.description.abstract | BACKGROUND: Although the pathogenesis of toluene diisocyanate (TDI)-induced occupational asthma (TDI-OA) is incompletely understood, several studies have suggested immunologic mechanisms, including specific IgE responses. A few studies have suggested human leukocyte antigen (HLA) associations with TDI-induced asthma in Western countries, but this is the first investigation of associations between HLA class I and II alleles and TDI-induced asthma patients in Asia, using high-resolution analysis. METHODS: Patients with TDI-OA (n = 84), asymptomatic exposed controls (AECs, n = 47) and unexposed normal controls (NCs, n = 127) were enrolled. HLA class I and II genotyping was performed by the direct DNA sequencing analysis. Specific serum IgE antibodies to the vapor type TDI-albumin conjugate were measured by ELISA. RESULTS: There was no significant association between the allele frequencies and the phenotype of TDI-OA. However, the frequency of the HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype was significantly higher in TDI-OA patients (19%) than in AEC (2.1%, p = 0.007, OR 4.429, CI 1.497-13.103) or NC (3.1%, p < 0.001, OR 7.235, CI 2.236-22.510) subjects, with statistical significance persisting after correction for multiple comparisons. DQB1*0402 was significantly associated with the presence of specific IgE to TDI-albumin conjugates in serum (p = 0.006, OR 4.552, CI 1.540-13.449). This p value remained significant after correction for multiple comparison. CONCLUSION: The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype may be a genetic marker for the development of TDI-induced asthma in Koreans. Several HLA alleles that enhance specific IgE sensitization in exposed subjects are indicated. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 156~163 | - |
dc.relation.isPartOf | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asthma/chemically induced* | - |
dc.subject.MESH | Asthma/genetics* | - |
dc.subject.MESH | Asthma/physiopathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Forced Expiratory Volume/physiology | - |
dc.subject.MESH | Gene Frequency/genetics | - |
dc.subject.MESH | HLA-DP Antigens/genetics* | - |
dc.subject.MESH | HLA-DP beta-Chains | - |
dc.subject.MESH | HLA-DQ Antigens/genetics* | - |
dc.subject.MESH | HLA-DQ beta-Chains | - |
dc.subject.MESH | HLA-DR Antigens/genetics* | - |
dc.subject.MESH | HLA-DRB1 Chains | - |
dc.subject.MESH | Haplotypes/genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E/blood | - |
dc.subject.MESH | Immunoglobulin E/immunology | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Glycoproteins/genetics* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Occupational Diseases/chemically induced | - |
dc.subject.MESH | Occupational Diseases/genetics* | - |
dc.subject.MESH | Occupational Diseases/immunology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Toluene 2,4-Diisocyanate/adverse effects* | - |
dc.subject.MESH | Toluene 2,4-Diisocyanate/immunology | - |
dc.title | The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jeong-Hee Choi | - |
dc.contributor.googleauthor | Kyung-Wha Lee | - |
dc.contributor.googleauthor | Cheol-Woo Kim | - |
dc.contributor.googleauthor | Choon-Sik Park | - |
dc.contributor.googleauthor | Hyun-Young Lee | - |
dc.contributor.googleauthor | Gyu-Young Hur | - |
dc.contributor.googleauthor | Seung-Hyun Kim | - |
dc.contributor.googleauthor | Chein-Soo Hong | - |
dc.contributor.googleauthor | An-Soo Jang | - |
dc.contributor.googleauthor | Hae-Sim Park | - |
dc.identifier.doi | 10.1159/000218118 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04448-1 | - |
dc.relation.journalcode | J01074 | - |
dc.identifier.eissn | 1423-0097 | - |
dc.identifier.pmid | 19439981 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/218118 | - |
dc.subject.keyword | Toluene diisocyanate | - |
dc.subject.keyword | Asthma | - |
dc.subject.keyword | Human leukocyte antigen class | - |
dc.subject.keyword | Immunoglobulin E | - |
dc.contributor.alternativeName | Hong, Chein Soo | - |
dc.contributor.affiliatedAuthor | Hong, Chein Soo | - |
dc.citation.volume | 150 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 156 | - |
dc.citation.endPage | 163 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Vol.150(2) : 156-163, 2009 | - |
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