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Prognostic factors and clinical outcomes of high-dose chemotherapy followed by autologous stem cell transplantation in patients with peripheral T cell lymphoma, unspecified: complete remission at transplantation and the prognostic index of peripheral T cell lymphoma are the major factors predictive of outcome

Authors
 Deok-Hwan Yang  ;  Won Seog Kim  ;  Seok Jin Kim  ;  Sung Hwa Bae  ;  Sung Hyun Kim  ;  In Ho Kim  ;  Sung Soo Yoon  ;  Yeung-Chul Mun  ;  Ho-Jin Shin  ;  Yee Soo Chae  ;  Jae-Yong Kwak  ;  Hawk Kim  ;  Min Kyoung Kim  ;  Jin Seok Kim  ;  Jong Ho Won  ;  Je-Jung Lee  ;  Cheol Won Suh 
Citation
 BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol.15(1) : 118-125, 2009 
Journal Title
 BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 
ISSN
 1083-8791 
Issue Date
2009
MeSH
Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Asian Continental Ancestry Group ; Hematopoietic Stem Cell Transplantation/methods* ; Hematopoietic Stem Cell Transplantation/mortality ; Humans ; Lymphoma, T-Cell, Peripheral/mortality ; Lymphoma, T-Cell, Peripheral/therapy* ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Analysis ; Transplantation, Autologous ; Treatment Outcome
Keywords
Peripheral T cell lymphoma ; Unspecified ; Clinical outcomes ; Prognostic factors
Abstract
High-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) offers a rescue option for T cell lymphoma patients with poor prognosis. However, the effectiveness of HDT/ASCT in patients with various peripheral T cell subtypes, optimal transplant timing, and the prognostic factors that predict better outcomes, have not been identified. We retrospectively investigated the clinical outcomes and prognostic factors for HDT/ASCT in 64 Korean patients with peripheral T cell lymphoma, unspecified (PTCL-U) between March 1995 and February 2007. The median age at transplantation was 44 years (range: 15-63 years). According to the age-adjusted International Prognostic Index (a-IPI) and the prognostic index of PTCL (PIT), 8 patients (12.5%) were in the high-risk group and 16 (26.6%) had the 2-3 PIT factors, respectively. After a median follow-up of 29.7 months, the 3-year overall survival (OS) and progression-free survival (PFS) rates were 53.0% +/- 7.5% and 44.3% +/- 7.0%, respectively. Univariate analysis showed that poor performance status, high lactate dehydrogenase (LDH) levels, high a-IPI score, high PIT classes, failure to achieve complete response (CR) at transplantation, and nonfrontline transplantation were associated with poor OS. Multivariate analysis showed that failure to achieve CR at transplantation (hazard ratio [HR] 2.23; 95% confidence interval [CI] 1.78-7.93) and 2-3 PIT factors (HR 3.76; 95% CI 1.02-5.42) were independent prognostic factors for OS. Failure to achieve CR at transplantation and high PIT are negative predictable factors for survival following HDT/ASCT in patients with PTCL-U.
Full Text
http://www.sciencedirect.com/science/article/pii/S1083879108005089
DOI
10.1016/j.bbmt.2008.11.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104797
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