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Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions.

Authors
 Sang Choel Lee  ;  Seung Hyeok Han  ;  Jin Ji Li  ;  Sun Ha Lee  ;  Dong-Sub Jung  ;  Seung-Jae Kwak  ;  Seung Hye Kim  ;  Dong Ki Kim  ;  Tae-Hyun Yoo  ;  Jin Hyun Kim  ;  Se-Ho Chang  ;  Dae Suk Han  ;  Shin-Wook Kang 
Citation
 Kidney International, Vol.76(8) : 838-848, 2009 
Journal Title
 Kidney International 
ISSN
 0085-2538 
Issue Date
2009
Abstract
Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose-treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose-treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions
Full Text
http://www.kidney-international.org/article/S0085-2538(15)54079-9/abstract
DOI
10.1038/ki.2009.286
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
Yonsei Authors
강신욱(Kang, Shin Wook) ORCID logo https://orcid.org/0000-0002-5677-4756
곽승재(Kwak, Seung Jae)
김동기(Kim, Dong Ki)
김승혜(Kim, Seung Hye)
유태현(Yoo, Tae Hyun) ORCID logo https://orcid.org/0000-0002-9183-4507
이순하(Lee, Sun Ha)
정동섭(Jung, Dong Sub)
한대석(Han, Dae Suk)
한승진(Han, Seung Jin)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104670
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